This study contributes to a better understanding of the immunological basis of PRRSV persistence.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:Regulatory T lymphocytes (T-regs) may be involved in suppressing the host’s immunity, which is importantfor viral clearance, and may therefore contribute to persistent viral infection.
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Temel Bulgular & Veri:This study, which used l ow cytometry and real-time PCR, determined that the frequencies of $CD4^ +CD25^ +$T-cells and porcine Forkhead/winged helix transcription factor (FoxP3) mRNA levels in peripheral blood signii cantlyincreased during PRRSV persistence, indicating that $CD4^ +CD25^ +$ T-regs might play an important role in PRRSVpersistent infection.
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Sonuç & Katkı:This study contributes to a better understanding of the immunological basis of PRRSV persistence.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Abstract
Regulatory T lymphocytes (T-regs) may be involved in suppressing the host’s immunity, which is importantfor viral clearance, and may therefore contribute to persistent viral infection. However, nothing is known regardingthe situation of porcine T-regs during persistent infection with porcine reproductive and respiratory syndrome virus(PRRSV). This study, which used l ow cytometry and real-time PCR, determined that the frequencies of $CD4^ +CD25^ +$T-cells and porcine Forkhead/winged helix transcription factor (FoxP3) mRNA levels in peripheral blood signii cantlyincreased during PRRSV persistence, indicating that $CD4^ +CD25^ +$ T-regs might play an important role in PRRSVpersistent infection. This study contributes to a better understanding of the immunological basis of PRRSV persistence.
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Bu Makaleye Atıf Yap
ZENG, J., GE, X., YANG, H., HE, D., GUO, X. (2022). The increase of $CD4^ +CD25^ +$ T cells in the peripheral blood of pigs persistently infected with porcine reproductive and respiratory syndrome virus. Turkish Journal of Veterinary and Animal Sciences, Cilt: 35 - Sayı: 3, 177–182. https://ajindex.com/articles/615348
Neumann, E.J., Kliebenstein, J.B., Johnson, C.D., Mabry, J.W., Bush, E.J., Seitzinger, A.H., Green, A.L., Zimmerman, J.J.: Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States. J. Am. Vet. Med. Assoc., 2005; 227: 385-392
Cavanaugh, D.: Nidovirales: a new order comprising coronaviridae and arteriviridae. Arch. Virol., 1997; 142: 629- 633
Cho, J.G., Dee, S.A.: Porcine reproductive and respiratory syndrome virus. h eriogenology, 2006; 66: 655-662
Allende, R., Laegreid, W.W., Kutish, G.F., Galeota, J.A., Wills, R.W., Osorio, F.A.: Porcine reproductive and respiratory syndrome virus: description of persistence in individual pigs upon experimental infection. J Virol., 2000; 74: 10834-10837
Batista, L., Pijoan, C., Dee, S., Olin, M., Molitor, T., Joo, H.S., Xiao, Z., Murtaugh, M.: Virological and immunological responses to porcine reproductive and respiratory syndrome virus in a large population of gilts. Can. J. Vet. Res., 2004; 68: 267-273
Wills, R.W., Doster, A.R., Galeota, J.A., Sur, J.H., Osorio, F.A.: Duration of infection and proportion of pigs persistently infected with porcine reproductive and respiratory syndrome virus. J. Clin. Microbiol., 2003; 41: 58-62
Plagemann, P.G., Moennig, V.: Lactate dehydrogenase- elevating virus, equine arteritis virus, and simian hemorrhagic fever virus: a new group of positive-strand RNA viruses. Adv. Virus Res., 1992; 41: 99-192
Mateu, E., Diaz, I.: h e challenge of PRRS immunology. Vet. J., 2008; 177: 345-351
Drew, T.W.: A review of evidence for immunosuppression due to porcine reproductive and respiratory syndrome virus. Vet. Res., 2000; 31: 27-39
Diaz, I., Darwich, L., Pappaterra, G., Pujols, J., Mateu, E.: Immune responses of pigs at er experimental infection with a European strain of porcine reproductive and respiratory syndrome virus. J. Gen. Virol., 2005; 86: 1943-1951
Lamontagne, L., Pagé, C., Larochelle, R., Magar, R.: Porcine reproductive and respiratory syndrome virus persistence in blood, spleen, lymph nodes, and tonsils of experimentally infected pigs depends on the level of CD8high T cells. Viral. Immunol., 2003; 16: 395-406
Xiao, Z., Batista, L., Dee, S., Halbur, P., Murtaugh, M.P.: h e level of virus-specii c T-cell and macrophage recruitment in porcine reproductive and respiratory syndrome vir