Dergiler / Turkish Journal of Veterinary and Animal Sciences / 2019 / Cilt: 43 - Sayı: 4

A preliminary study on effects of subanesthetic doses of preemptive ketamine given prior to premedication on total intravenous anesthesia for short- to medium-term surgical procedures in horses

Sayfa
456–468
Yayın Tarihi
2022-11-05
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Fluctuation in pain scores at 1 h and 2 h after the endof surgery was minimum in group HK.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:This study was conducted to determine the effects of subanesthetic doses of ketamine given prior to premedication on thequality of anesthesia, recovery, and postoperative pain in horses.
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Temel Bulgular & Veri:Eighteen horses were randomly recruited into three equal groups, S,LK, and HK, wherein saline, ketamine at 0.2 mg/kg body weight (bwt), and ketamine at 0.4 mg/kg bwt were given, respectively, i.v. for 30min as a continuous rate infusion (CRI).
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Sonuç & Katkı:Fluctuation in pain scores at 1 h and 2 h after the endof surgery was minimum in group HK.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

This study was conducted to determine the effects of subanesthetic doses of ketamine given prior to premedication on thequality of anesthesia, recovery, and postoperative pain in horses. Eighteen horses were randomly recruited into three equal groups, S,LK, and HK, wherein saline, ketamine at 0.2 mg/kg body weight (bwt), and ketamine at 0.4 mg/kg bwt were given, respectively, i.v. for 30min as a continuous rate infusion (CRI). Horses were premedicated with xylazine at 1 mg/kg bwt i.v. and butorphanol at 0.05 mg/kg bwti.v. after 30 min. Anesthesia was induced using ketamine and midazolam and was maintained with ketamine at 2 mg/kg/h as CRI, andbolus doses of thiopental 5% solution was given i.v. whenever necessary. Preemptive ketamine infusion clinically enhanced the qualityof sedation and enabled smooth induction with significantly (P < 0.05) higher sedation and postinfusion ataxia and shorter down-time(P < 0.05) in group HK. Physiological, hematological, serological, and vital parameters remained within normal limits. All the horsesrecovered well without any adverse effects and stood in less than 2 h after surgery. Fluctuation in pain scores at 1 h and 2 h after the endof surgery was minimum in group HK.

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Bu Makaleye Atıf Yap

JOHN, C., VERMA, M. R., SARANGOM, S. B., SHARMA, P., SOWBHARENYA, C., GOPINATHAN, A., SINGH, K. (2022). A preliminary study on effects of subanesthetic doses of preemptive ketamine given prior to premedication on total intravenous anesthesia for short- to medium-term surgical procedures in horses. Turkish Journal of Veterinary and Animal Sciences, Cilt: 43 - Sayı: 4, 456–468. https://ajindex.com/articles/614832

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Kaynakça (12)

  1. Visser E, Schug SA. The role of ketamine in pain management. Biomed Pharmacother 2006; 60: 341-348
  2. Sarton E, Teppema LJ, Olievier C, Nieuwenhuijs D, Matthes HW, Kieffer BL, Dahan A. The involvement of the mu-opioid receptor in ketamine-induced respiratory depression and antinociception. Anesth Analg 2001; 93: 1495-1500
  3. McMurphy RM, Young LE, Marlin DJ, Walsh K. Comparison of the cardiopulmonary effects of anesthesia maintained by continuous infusion of romifidine, guaifenesin, and ketamine with anesthesia maintained by inhalation of halothane in horses. Am J Vet Res 2002; 63: 1655-1661
  4. Mama KR, Wagner AE, Steffey EP, Kollias-Baker C, Hellyer PW, Golden AE, Brevard LF. Evaluation of xylazine and ketamine for total intravenous anesthesia in horses. Am J Vet Res 2005; 66: 1002-1007
  5. Peterbauer C, Larenza PM, Knobloch M, Theurillat R, Thormann W, Mevissen M, Spadavecchia C. Effects of a low dose infusion of racemic and S-ketamine on the nociceptive withdrawal reflex in standing ponies. Vet Anaesth Analg 2008; 35: 414-423
  6. Wagner AE, Mama KR, Contino EK, Ferris DJ, Kawcak CE. Evaluation of sedation and analgesia in standing horses after administration of xylazine, butorphanol, and subanesthetic doses of ketamine. J Am Vet Med Assoc 2011; 238: 1629-1633
  7. Guedes AG, Matthews NS, Hood DM. Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitis-associated pain. Am J Vet Res 2012; 73: 610-619
  8. Fielding CL, Brumbaugh G, Matthews NS, Peck KE, Roussel AJ. Pharmacokinetics and clinical effects of a subanesthetic continuous rate infusion of ketamine in awake horses. Am J Vet Res 2006; 67: 1484-1690
  9. Lankveld DPK, Driessen B, Soma LR, Moate PJ, Rudy J, Uboh CE, Van Dijk P, Hellebrekers LJ. Pharmacodynamic effects and pharmacokinetic profile of a long-term continuous rate infusion of racemic ketamine in healthy conscious horses. J Vet Pharmacol Ther 2006; 29: 477-488
  10. Taylor PM. Equine stress responses to anaesthesia. Br J Anaesth 1989; 63: 702-709
  11. Lankveld DPK, Bull S, Van Dijk P, Fink-Gremmels J, Hellebrekers LJ. Ketamine inhibits LPS-induced tumour necrosis factoralpha and interleukin-6 in an equine macrophage cell line. Vet Res 2005; 36: 257-262
  12. Kushiro T, Yamashita K, Umar MA, Maehara S, Wakaiki S, Abe R, Seno T, Tsuzuki K, Izumisawa Y, Muir WW. Anesthetic and cardiovascular effects of balanced anesthesia using constant rate infusion of midazolam-ketamin