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Dergiler / Turkish Journal of Veterinary and Animal Sciences / 2020 / Cilt: 44 - Sayı: 3

Association of toll-like receptor 4 (TLR 4) gene exon 3 variants with serostatus of the ovine Johne’s disease (paratuberculosis) in Turkish sheep

Yalçın YAMAN
Sayfa
542–547
Yayın Tarihi
2022-11-05
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

As a consequence, within the detection limits(power, 0.95; odds ratio > 3.3), no association was detected between the OJD serostatus and TLR4 exon 3 coding variants in Turkishsheep.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In the present study, the effect of exon 3 of the toll-like receptor 4 (TLR4) gene on ovine Johne’s disease (OJD) serostatus wastested in Turkish sheep breeds.
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Temel Bulgular & Veri:Initially, a retrospective cohort was performed using indirect ELISA on a commingled flock consistingof 3 native and 4 composite breeds (n = 1750).
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Sonuç & Katkı:As a consequence, within the detection limits(power, 0.95; odds ratio > 3.3), no association was detected between the OJD serostatus and TLR4 exon 3 coding variants in Turkishsheep.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

In the present study, the effect of exon 3 of the toll-like receptor 4 (TLR4) gene on ovine Johne’s disease (OJD) serostatus wastested in Turkish sheep breeds. Initially, a retrospective cohort was performed using indirect ELISA on a commingled flock consistingof 3 native and 4 composite breeds (n = 1750). Case-control matched pairs were constructed according to the breed type and age (n= 188). Subsequently, exon 3 of the TLR4 gene was sequenced and coding variants were investigated. A total of 15 single nucleotidepolymorphisms (SNPs) were detected and 12 of those SNPs were nonsynonymous. Next, 3 haplotype blocks consisting of these SNPswere constructed. The McNemar’s test was conducted on both the SNPs and haplotypes. As a consequence, within the detection limits(power, 0.95; odds ratio > 3.3), no association was detected between the OJD serostatus and TLR4 exon 3 coding variants in Turkishsheep.

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Bu Makaleye Atıf Yap

YAMAN, Y. (2022). Association of toll-like receptor 4 (TLR 4) gene exon 3 variants with serostatus of the ovine Johne’s disease (paratuberculosis) in Turkish sheep. Turkish Journal of Veterinary and Animal Sciences, Cilt: 44 - Sayı: 3, 542–547. https://ajindex.com/articles/614730

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