Dergiler / Turkish Journal of Veterinary and Animal Sciences / 2020 / Cilt: 44 - Sayı: 2

Expression profiles of lincRNA and mRNA related to milk yield and milk composition traits in the milk-derived exosomes of Holstein and Doğu Anadolu Kırmızısı cows

Sayfa
227–234
Yayın Tarihi
2022-11-04
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These lincRNAs and mRNAs, which are carried in the milkderivedexosomes, could be utilized in animal breeding programs to enhance milk yield and composition traits.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:This study aimed to demonstrate the expression profiles of lincRNAs and mRNAs affecting milk yield and composition traitsin the milk-derived exosomes of Holstein and Doğu Anadolu Kırmızısı (DAK) cows.
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Temel Bulgular & Veri:Lastly, correlation analysis was carried out between milk yield data from Holstein and DAK cows andexpression levels of the lincRNAs and mRNAs.
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Sonuç & Katkı:These lincRNAs and mRNAs, which are carried in the milkderivedexosomes, could be utilized in animal breeding programs to enhance milk yield and composition traits.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

This study aimed to demonstrate the expression profiles of lincRNAs and mRNAs affecting milk yield and composition traitsin the milk-derived exosomes of Holstein and Doğu Anadolu Kırmızısı (DAK) cows. For this purpose, the locations of these specificlincRNAs and mRNAs were confirmed in quantitative trait loci. Then RT-PCR analysis was performed to identify the expression profilesof the lincRNAs and mRNAs. Lastly, correlation analysis was carried out between milk yield data from Holstein and DAK cows andexpression levels of the lincRNAs and mRNAs. The findings showed that while lincRNAs and mRNAs associated with milk yield traitswere upregulated in the Holstein cows exhibiting high milk yield in comparison to the DAK cows exhibiting low milk yield, lincRNAand mRNA associated with milk composition traits were downregulated in the Holstein cows with high milk yield compared to theDAK cows with low milk yield. These results suggest primary evidence for expression profiles of lincRNA and mRNA related to milkproduction traits in the milk-derived exosomes of Holstein and DAK cows. These lincRNAs and mRNAs, which are carried in the milkderivedexosomes, could be utilized in animal breeding programs to enhance milk yield and composition traits.

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Bu Makaleye Atıf Yap

ÖZDEMİR, S., ÇULHA, M. H., ELTAS, Ö. (2022). Expression profiles of lincRNA and mRNA related to milk yield and milk composition traits in the milk-derived exosomes of Holstein and Doğu Anadolu Kırmızısı cows. Turkish Journal of Veterinary and Animal Sciences, Cilt: 44 - Sayı: 2, 227–234. https://ajindex.com/articles/614729

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Kaynakça (12)

  1. van Hooijdonk AC, Kussendrager KD, Steijns JM. In vivo antimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defence. The British Journal of Nutrition 2000
  2. 84 (1): 127-134. doi: 10.1017/ s000711450000235x 2. Egger-Danner C, Cole JB, Pryce JE, Gengler N, Heringstad B et al. Invited review: overview of new traits and phenotyping strategies in dairy cattle with a focus on functional traits. Animal: An International Journal of Animal Bioscience 2015
  3. 9 (2): 191-207. doi: 10.1017/s1751731114002614 3. Oliveira HR, Cant JP, Brito LF, Feitosa FLB, Chud TCS et al. Genome-wide association for milk production traits and somatic cell score in different lactation stages of Ayrshire, Holstein, and Jersey dairy cattle. Journal of Dairy Science 2019
  4. 102 (9): 8159-8174. doi: 10.3168/jds.2019-16451 4. Jiang J, Liu L, Gao Y, Shi L, Li Y et al. Determination of genetic associations between indels in 11 candidate genes and milk composition traits in Chinese Holstein population. BMC Genetics 2019
  5. 20 (1): 48. doi: 10.1186/s12863-019-0751-y 5. Seno LO, Guidolin DGF, Aspilcueta-Borquis RR, Nascimento GBD, Silva T et al. Genomic selection in dairy cattle simulated populations. Journal of Dairy Research 2018
  6. 85 (2): 125-132. doi: 10.1017/s0022029918000304 6. Thery C, Amigorena S, Raposo G, Clayton A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Current Protocols in Cell Biology 2006
  7. Chapter 3: Unit 3.22. doi: 10.1002/0471143030.cb0322s30 7. Ono S, Lam S, Nagahara M, Hoon DS. Circulating microRNA biomarkers as liquid biopsy for cancer patients: pros and cons of current assays. Journal of Clinical Medicine 2015
  8. 4 (10): 1890-1907. doi: 10.3390/jcm4101890 8. Reinhardt TA, Lippolis JD, Nonnecke BJ, Sacco RE. Bovine milk exosome proteome. Journal of Proteomics 2012
  9. 75 (5): 1486-1492. doi: 10.1016/j.jprot.2011.11.017 9. Hata T, Murakami K, Nakatani H, Yamamoto Y, Matsuda T et al. Isolation of bovine milk-derived microvesicles carrying mRNAs and microRNAs. Biochemical and Biophysical Research Communications 2010
  10. 396 (2): 528-533. doi: 10.1016/j.bbrc.2010.04.135 10. Ulitsky I, Bartel DP. lincRNAs: genomics, evolution, and mechanisms. Cell 2013
  11. 154 (1): 26-46. doi: 10.1016/j. cell.2013.06.020 11. Ulitsky I. Evolution to the rescue: using comparative genomics to understand long non-coding RNAs. Nature Reviews Genetics 2016
  12. 17 (10): 601-614. doi: 10.1038/nrg.2016.85 12. Geisler S,