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AI InsightThe study suggests that abnormalities of both right and left ventricular diastolic function may occur, and should be searched for, in pédiatrie patients with dilated cardiomyopathy.
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Abstract
We evaluated left and right ventricular diastolic functions by pulsed Doppler echocardiography in 16 children with dilated cardiomyopathy and in 20 healthy age-matched control subjects. The cardiomyopathy group demonstrated an abnormal relaxation pattern of the left ventricle. In the cardiomyopathy group compared to normal subjects, peak early filling velocities (43.3 ±11 cm/s versus 60.4 ± 11 cms/s, p < 0.01), the corresponding velocity-time integrals (3.3 ± 1.4 cm versus 4.6 ± 1.2 cm, p < 0.01) and the ratio of peak early filling velocity to late filling velocity (1.22 ± 0.47 versus 1.49 ± 0.23, p < 0.05) were significantly lower whereas isovolumic relaxation time was significantly longer (58.9 ± 19.8 ms versus 49.7 ± 8.9 ms, p < 0.05). In addition, right ventricular diastolic filling was also impaired in children with dilated cardiomyopathy. Peak early filling velocities (41 ± 7.9 cm/s versus 47.5 ± 8.8 cm/s, p < 0.05) and the corresponding velocity time integrals (3.0 ± 1.0 cm versus 3.87 ± 1.1 cm, p < 0.05) were significantly decreased, while isovolumic relaxation time was significantly increased (60.6 ±16.3 ms versus 52.2 ±12.8 ms, p < 0.05) in the cardiomyopathy group. The study suggests that abnormalities of both right and left ventricular diastolic function may occur, and should be searched for, in pédiatrie patients with dilated cardiomyopathy.