The Frailty of Advanced Kidney Disease: The Role of Mitochondria

Temel Bulgular & Veri:Mitochondrial dysfunction also plays an essential role in the pathogenesis of sarcopenia in chronic kidney disease patients.

💡

Sonuç & Katkı:It may be feasible to assess the effect of mitochondrial-targeted drugs to treat sarcopenia in patients with chronic kidney disease.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Abstract

Uremic toxins contribute to the impairment of mitochondrial function that subsequently could result in organ failure. Mitochondrial dysfunction also plays an essential role in the pathogenesis of sarcopenia in chronic kidney disease patients. It may be feasible to assess the effect of mitochondrial-targeted drugs to treat sarcopenia in patients with chronic kidney disease.

🔖

Bu Makaleye Atıf Yap

İKİZLER, T. A., YILDIZ, A. (2022). The Frailty of Advanced Kidney Disease: The Role of Mitochondria. Turkish journal of nephrology (Online), Cilt: 31 - Sayı: 3, 190–193. https://ajindex.com/articles/612809

📄 Tam Metin PDF Okuyucu

Yeni Sekmede Aç ↗

↗Yeni Sekme

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (3)

Horscroft JA, Kotwica AO, Laner V, et al. Metabolic basis to Sherpa altitude adaptation. Proc Natl Acad Sci USA. 2017;114(24):6382- 6387. [CrossRef]
Gamboa JL, Billings F, Bojanowski MT, et al. Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease. Physiol Rep. 2016;4:e12780
Oliveira EA, Cheung WW, Toma KG, Mak RH. Muscle wasting in chronic kidney disease. Pediatr Nephrol. 2018;33(5):789-798. [CrossRef] 4. Gamboa JL, Roshanravan B, Towse T, et al. Skeletal muscle mitochondrial dysfunction is present in patients with CKD before initiation of maintenance hemodialysis. Clin J Am Soc Nephrol. 2020;15(7):926-936. [CrossRef] 5. Wang S, LuoH. Dating Alphaproteobacteria evolution with eukaryotic fossils. Nat Commun. 2021;12(1):3324. [CrossRef] 6. Supinski GS, Schroder EA, Callahan LA. Mitochondria and critical illness. Chest. 2020;157(2):310-322. [CrossRef] 7. Palikaras K, Lionaki E, Tavernarakis N. Mechanisms of mitophagy in cellular homeostasis, physiology and pathology. Nat Cell Biol. 2018;20(9):1013-1022. [CrossRef] 8. Abate M, Festa A, Falco M, et al. Mitochondria as playmakers of apoptosis, autophagy and senescence. Semin Cell Dev Biol. 2020;98:139-153. [CrossRef] 9. Subramanya AR, Ellison DH. Distal convoluted tubule. Clin J Am Soc Nephrol. 2014;9(12):2147-2163. [CrossRef] 10. Curthoys NP, Moe OW. Proximal tubule function and response to acidosis. Clin J Am Soc Nephrol. 2014;9(9):1627-1638. [CrossRef] 11. Tang C, Cai J, Yin XM, Weinberg JM, Venkatachalam MA, Dong Z. Mitochondrial quality control in kidney injury and repair. Nat Rev Nephrol. 2021;17(5):299-318. [CrossRef] 12. Ertuglu L, Yildiz A, Gamboa J, Ikizler TA. Skeletal muscle energetics in patients with moderate to advanced kidney disease. Kidney Res Clin Pract. 2022;41(1):14-21. [CrossRef] 13. Siew ED, Ikizler TA. Determinants of insulin resistance and its effects on protein metabolism in patients with advanced chronic kidney disease. Contrib Nephrol. 2008;161:138-144. [CrossRef] 14. Carrero JJ, Stenvinkel P, Cuppari L, et al. Etiology of the proteinenergy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). J Ren Nutr. 2013;23(2):77-90. [CrossRef] 15. Gamboa JL, Deger SM, Perkins BW, et al. Effects of long-term intradialytic oral nutrition and exercise on muscle protein homeostasis and markers of mitochondrial content in patients on hemodialysis. Am J Physiol Ren Physio