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AI InsightIt was concluded that the growth hormone had positive effects on hepatic regeneration.
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Özet
The aim of this experimental study was to determine the effects of growth hormone on hepatic regeneration after partial hepatectomy. Thirty pathogen free Sprague-Dawley rats were divided into three groups, each containing 10 rats. The animals were subjected to a sham operation in Group 1, and to left hepatic lobectomy in Groups 2 and 3. The animals in Groups 1 and 2 received saline solution (0.2 mg/kg/day), while growth hormone (Lilly Humotrope, Lilly France Usine de Fegersheim, France) (0.2 mg/kg/day) was given to the animals in Group 3 for seven days. On the seventh postoperative day, the animals were sacrificed and total hepatectomy was performed. The mitosis rate of the hepatocytes and Ki-67 monoclonal antibody positivity were determined. The animals in Group 3 exhibited a higher hepatocyte mitosis rate and greater Ki-67 monoclonal antibody positivity than the animals in Groups 1 and 2. It was concluded that the growth hormone had positive effects on hepatic regeneration.
Abstract
The aim of this experimental study was to determine the effects of growth hormone on hepatic regeneration after partial hepatectomy. Thirty pathogen free Sprague-Dawley rats were divided into three groups, each containing 10 rats. The animals were subjected to a sham operation in Group 1, and to left hepatic lobectomy in Groups 2 and 3. The animals in Groups 1 and 2 received saline solution (0.2 mg/kg/day), while growth hormone (Lilly Humotrope, Lilly France Usine de Fegersheim, France) (0.2 mg/kg/day) was given to the animals in Group 3 for seven days. On the seventh postoperative day, the animals were sacrificed and total hepatectomy was performed. The mitosis rate of the hepatocytes and Ki-67 monoclonal antibody positivity were determined. The animals in Group 3 exhibited a higher hepatocyte mitosis rate and greater Ki-67 monoclonal antibody positivity than the animals in Groups 1 and 2. It was concluded that the growth hormone had positive effects on hepatic regeneration.