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Dergiler / Turkish Journal of Medical Sciences / 2005 / Cilt: 35 - Sayı: 3

Insulin-like growth factor binding protein-I; a rapid detection of amniotic fluid leakage after amniocentesis

Pınar ÇAKMAK
Perran MOROY
Nuri DANIŞMAN
Leyla MOLLAMAHMUTOĞLU
Ayhan SUCAK
Tamer MUNGAN
Sayfa
157–161
Yayın Tarihi
2022-11-05
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In conclusion the detection of vaginal IGFBP-I is highly predictive for amniotic fluid leakage especially in clinically doubtful cases.

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Amaç & Hipotez:The aim of this study was to assess the diagnostic value of vaginal insulin-like growth factor binding protein-1 (IGFBP-I) in the detection of amniotic fluid leakage after amniocentesis.
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Temel Bulgular & Veri:It includes 58 healthy pregnant women who successfully underwent amniocentesis at 15-20 weeks of gestation.
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Sonuç & Katkı:In conclusion the detection of vaginal IGFBP-I is highly predictive for amniotic fluid leakage especially in clinically doubtful cases.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

The aim of this study was to assess the diagnostic value of vaginal insulin-like growth factor binding protein-1 (IGFBP-I) in the detection of amniotic fluid leakage after amniocentesis. It includes 58 healthy pregnant women who successfully underwent amniocentesis at 15-20 weeks of gestation. After amniocentesis patients were evaluated for amniotic fluid leakage at 60 min, 48 h, and 6 weeks after the procedure with speculum examination, nitrazine paper test and microscopic evidence of ferning, and were grouped into Group I (at least 2 positive tests) and Group II (others) according to the first evaluation. All patients tested for vaginal IGFBP-I. A total of 1.1% (7/58) of patients met the Group I criteria. Vaginal bleeding and contraction occurrence was nonsignificantly higher in Group I. One false positive and one false negative result were obtained from IGFBP-I testing. The sensitivity of this test was 85%, specificity was 98%, positive predictive value (PPV) was 85% and negative predictive value (NPV) was 98%. After 48 h the sensitivity of this test was 75%, specificity was 98%, PPV was 75% and NPV was 98%. Results at the 6th week were similar to those at 48 h. In conclusion the detection of vaginal IGFBP-I is highly predictive for amniotic fluid leakage especially in clinically doubtful cases.

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Bu Makaleye Atıf Yap

ÇAKMAK, P., MOROY, P., DANIŞMAN, N., MOLLAMAHMUTOĞLU, L., SUCAK, A., MUNGAN, T. (2022). Insulin-like growth factor binding protein-I; a rapid detection of amniotic fluid leakage after amniocentesis. Turkish Journal of Medical Sciences, Cilt: 35 - Sayı: 3, 157–161. https://ajindex.com/articles/611988

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Kaynakça (12)

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