KaydedilenlerDerginizi ekleyin

Dergiler / Turkish Journal of Medical Sciences / 2009 / Cilt: 39 - Sayı: 3

Plasma resistin and leptin levels in overweight and lean patients with rheumatoid arthritis

Ayşe Dicle TURHANOĞLU
Abdurrahman KAPLAN
Ebru KALE
Şehmus ÖZMEN
Ceyla OGÜN
Naime CANORUÇ
Sayfa
447–451
Yayın Tarihi
2022-11-05
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusions: Studies including more RA patients might be needed to define the role of leptin and resistin in RA subjects.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: Adipocytokines are now considered important players in the etiopathogenesis of numerous metabolic and inflammatory disorders.
📊
Temel Bulgular & Veri:Materials and Methods: Consecutive 52 patients with RA were compared with 52 control subjects in terms of mean leptin and resistin levels.
💡
Sonuç & Katkı:Conclusions: Studies including more RA patients might be needed to define the role of leptin and resistin in RA subjects.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Rheumatoid arthritis · Leptin · Resistin

Özet

Aim: Adipocytokines are now considered important players in the etiopathogenesis of numerous metabolic and inflammatory disorders. However, plasma leptin and resistin levels in rheumatoid arthritis (RA) are still unclear. We aimed to investigate the plasma levels of leptin and resistin in patients with rheumatoid arthritis and to compare them with controls. Materials and Methods: Consecutive 52 patients with RA were compared with 52 control subjects in terms of mean leptin and resistin levels. Results: Patients with RA showed considerably higher plasma levels of leptin (34.3 ± 27.9 vs. 11.1 ± 4.1) and resistin (4.8 ± 0.7 vs. 4.0 ± 1.3) than healthy controls (P < 0.0001). There was no significant difference regarding age, duration of disease, sex, CRP, and leptin and resistin levels between overweight and lean RA subjects. Plasma leptin level was significantly correlated with ESR (Erythrocyte Sedimentation Rate) (r = 0.287, P = 0.039) and swollen and tender joint count (r = 0.563, P < 0.0001) but not with resistin in subjects with RA. Measuring the plasma leptin level may be a potential marker of disease activity in RA. Conclusions: Studies including more RA patients might be needed to define the role of leptin and resistin in RA subjects.

Abstract

Aim: Adipocytokines are now considered important players in the etiopathogenesis of numerous metabolic and inflammatory disorders. However, plasma leptin and resistin levels in rheumatoid arthritis (RA) are still unclear. We aimed to investigate the plasma levels of leptin and resistin in patients with rheumatoid arthritis and to compare them with controls. Materials and Methods: Consecutive 52 patients with RA were compared with 52 control subjects in terms of mean leptin and resistin levels. Results: Patients with RA showed considerably higher plasma levels of leptin (34.3 ± 27.9 vs. 11.1 ± 4.1) and resistin (4.8 ± 0.7 vs. 4.0 ± 1.3) than healthy controls (P < 0.0001). There was no significant difference regarding age, duration of disease, sex, CRP, and leptin and resistin levels between overweight and lean RA subjects. Plasma leptin level was significantly correlated with ESR (Erythrocyte Sedimentation Rate) (r = 0.287, P = 0.039) and swollen and tender joint count (r = 0.563, P < 0.0001) but not with resistin in subjects with RA. Measuring the plasma leptin level may be a potential marker of disease activity in RA. Conclusions: Studies including more RA patients might be needed to define the role of leptin and resistin in RA subjects.

🔖

Bu Makaleye Atıf Yap

TURHANOĞLU, A. D., KAPLAN, A., KALE, E., ÖZMEN, Ş., OGÜN, C., CANORUÇ, N. (2022). Plasma resistin and leptin levels in overweight and lean patients with rheumatoid arthritis. Turkish Journal of Medical Sciences, Cilt: 39 - Sayı: 3, 447–451. https://ajindex.com/articles/611718

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (6)

  1. Steppan CM, Lazar MA The current biology of resistin. J Intern Med 2004; 255(4): 439-447.
  2. Reilly MP, Lehreke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ Resistin is an inflammatory marker of atheroscle- rosis in humans. Circulation 2005; 111(7): 932-9.
  3. Migita K, Maeda Y, Miyashita T, Kimura H, Nakamura M, Ishibashi H et al. The serum levels of resistin in rheumatoid arthritis patients. Clin Exp Rheumatol 2006; 24(6): 698-701
  4. Senolt L, Housa D, Vernerova Z, Jirasek T, Svobodova R, Veigl D, et al. Resistin is abundantly present in rheumatoid arthritis synovial tissue, synovial fluid, and elevated serum resistin reflects disease activity. Ann Rheum Dis 2007; 66: 458 Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A Resistin, an adipokine with potent proinflammatory proper- ties.J Immunol 2005; 174(9): 5789-5795
  5. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315–324
  6. Lee SW, Park MC, Park YB, Lee SK Measurement of the serum leptin level could assist disease activity monitoring in rheumatoid arthritis. Rheumatol Int 2007; 27(6): 537-540.