KaydedilenlerDerginizi ekleyin

Dergiler / Turkish Journal of Medical Sciences / 2012 / Cilt: 42 - Sayı: 5

Effects of etomidate on blood cortisol, insulin, and glucose levels and PONV rates in smokers

Eff ects of etomidate on blood cortisol, insulin, and glucose levels and PONV rates in smokers

Ayşe Belin ÖZER
Fuat YILDIZ
Ömer Lütfi ERHAN
Cevdet SÜMER
Sayfa
810–815
Yayın Tarihi
2022-11-05
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: We determined that the use of etomidate causes a lower stress response and more PONV compared to propofol, while smoking increases the stress response and decreases PONV.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:To observe differences in the effects of etomidate, used for anesthesia induction, on surgery-induced endocrine response and postoperative nausea and vomiting (PONV) among nonsmokers and smokers.
📊
Temel Bulgular & Veri:Materials and methods: Eighty adult patients with ASA I-II risk status were randomly divided into 2 groups: smokers (Group I, n = 40) and nonsmokers (Group II, n = 40).
💡
Sonuç & Katkı:Conclusion: We determined that the use of etomidate causes a lower stress response and more PONV compared to propofol, while smoking increases the stress response and decreases PONV.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Key words: Anesthesia · smoking · cortisol

Özet

To observe differences in the effects of etomidate, used for anesthesia induction, on surgery-induced endocrine response and postoperative nausea and vomiting (PONV) among nonsmokers and smokers. Materials and methods: Eighty adult patients with ASA I-II risk status were randomly divided into 2 groups: smokers (Group I, n = 40) and nonsmokers (Group II, n = 40). Patients were then further divided into subgroups according to the drug used for anesthesia induction, either propofol (Group IP and Group IIP) or etomidate (Group IE and Group IIE). Blood cortisol, insulin, glucose, and white blood cell (WBC) levels were measured and PONV scores were recorded. Results: Blood cortisol values were significantly lower in Group IE and Group IIE compared to Group IP and Group IIP during the 1st and 2nd hours after induction. By the 8th hour, blood insulin levels had increased significantly compared to the baseline values in Groups IE, IP, and IIP. Blood glucose levels were significantly higher in Group IIE compared to both Group IP and Group IIP. There was no significant difference between the WBC levels of the different groups. PONV scores were significantly higher in Group IIE compared to the other groups. Conclusion: We determined that the use of etomidate causes a lower stress response and more PONV compared to propofol, while smoking increases the stress response and decreases PONV.

Abstract

To observe differences in the effects of etomidate, used for anesthesia induction, on surgery-induced endocrine response and postoperative nausea and vomiting (PONV) among nonsmokers and smokers. Materials and methods: Eighty adult patients with ASA I-II risk status were randomly divided into 2 groups: smokers (Group I, n = 40) and nonsmokers (Group II, n = 40). Patients were then further divided into subgroups according to the drug used for anesthesia induction, either propofol (Group IP and Group IIP) or etomidate (Group IE and Group IIE). Blood cortisol, insulin, glucose, and white blood cell (WBC) levels were measured and PONV scores were recorded. Results: Blood cortisol values were significantly lower in Group IE and Group IIE compared to Group IP and Group IIP during the 1st and 2nd hours after induction. By the 8th hour, blood insulin levels had increased significantly compared to the baseline values in Groups IE, IP, and IIP. Blood glucose levels were significantly higher in Group IIE compared to both Group IP and Group IIP. There was no significant difference between the WBC levels of the different groups. PONV scores were significantly higher in Group IIE compared to the other groups. Conclusion: We determined that the use of etomidate causes a lower stress response and more PONV compared to propofol, while smoking increases the stress response and decreases PONV.

🔖

Bu Makaleye Atıf Yap

ÖZER, A. B., YILDIZ, F., ERHAN, Ö. L., SÜMER, C. (2022). Effects of etomidate on blood cortisol, insulin, and glucose levels and PONV rates in smokers. Turkish Journal of Medical Sciences, Cilt: 42 - Sayı: 5, 810–815. https://ajindex.com/articles/611206

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (14)

  1. Rodrigo C. Th e eff ects of cigarette smoking on anesthesia. Anesth Prog 2000; 47: 143-150.
  2. Wagner RL, White RF, Kan PG, Rosenthal MH, Feldman D. Inhibition of adrenal steroidogenesis by the anesthetic etomidate. N Engl J Med 1984; 310: 1415-21. 9. Figueroa M. Th e postanesthesia recovery score: a second look. Southern Medical Journal 1972; 65: 791-5.
  3. Dönmez A, Kaya H, Haberal A, Kutsal A, Arslan G. Th e eff ect of etomidate induction on plasma cortisol levels in children undergoing cardiac surgery. J Cardiothorac Vasc Anesth 1998; 12: 182-5.
  4. Crozier TA, Schlaeger M, Wuttke W, Kettler D. TIVA with etomidate-fentanyl versus midazolam-fentanyl. Th e perioperative stress of coronary surgery overcomes the inhibition of cortisol synthesis caused by etomidate-fentanyl anesthesia. Anaesthesist 1994; 43: 605-13.
  5. Fragen RJ, Weiss HW, Molteni A. Th e eff ect of propofol on adrenocortical steroidogenesis: a comparative study with etomidate and thiopental. Anesthesiology 1987; 66: 839-42.
  6. Lambert A, Mitchell R, Robertson WR. Eff ect of propofol, thiopentone and etomidate on adrenal steroidogenesis in vitro. Br J Anaesth 1985; 57: 505-8.
  7. Ng AS, Tan SS, Lee HS, Chew SL. Eff ect of propofol infusion on the endocrine response to cardiac surgery. Anaesth Intensive Care 1995; 23: 543-7.
  8. Fuxe K, Andersson K, Eneroth P, Harfstrand A, Agnati LF. Neuroendocrine actions of nicotine and of exposure to cigarette smoke: medical implications. Psychoneuroendocrinology 1989; 14: 19-41.
  9. Kawakami N, Takatsuka N, Shimizu H, Ishibashi H. Eff ects of smoking on incidence of non-insulin dependent diabetes mellitus. Am J Epidemiol. 1997; 15:103-9.
  10. Eliasson B, Mero N, Taskinen MR, Smith U. Th e insulin resistance syndrome and postprandial lipid intolerance in smokers. Atherosclerosis 1997; 129: 79-88.
  11. Daniel M, Cargo MD. Association between smoking, insulin resistance and beta-cell function in a North-western First Nation. Diabetic Medicine 2004; 21, 188-193.
  12. Wareham NJ, Ness EM, Byrne CD, Cox BD, Day NE, Hales CN. Cigarette smoking is not associated with hyperinsulinemia: Evidence against a causal relationship between smoking and insulin resistance. Metabolism 1996; 45: 1551-6.
  13. Pirbudak L, Balat O, Çekmen M, Ugur MG, Aygün S, Öner U. Eff ect of ascorbic acid on surgical stress response in gynecologic surgery. Int J Clin Pract 2004; 58: 928-31.
  14. Myles PS, Buckland MR, Morgan DJ, Weeks AM. Serum lipid and glucose concentrations with a propofol infusion for cardiac surgery. J Cardiothorac Vasc A