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Dergiler / Turkish Journal of Medical Sciences / 2013 / Cilt: 43 - Sayı: 2

The effect of combined treatment of alpha-tocopherol, ascorbic acid, and pyridoxine with NMDA blocker memantine on penicillin-induced epileptiform activity in rats

Mehmet YILDIRIM
Mustafa AYYILDIZ
Erdal AĞAR
Duygu AYDIN
Sayfa
245–250
Yayın Tarihi
2022-11-05
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Since moderate doses of these vitamins have no side effects, it might be a good idea to use them with NMDA blockers to provide an earlier antiepileptic effect.

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Amaç & Hipotez:To evaluate the effects of coadministration of vitamins alpha-tocopherol, ascorbic acid, and pyridoxine with memantine on a penicillin-induced experimental epilepsy model in rats so as to clarify the eventual interaction between these vitamins and the N-methyl-D-aspartate (NMDA) system.
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Temel Bulgular & Veri:Results: The antiepileptiform effects appeared earlier in all memantine and vitamin coadministrated groups compared to the memantine-alone group, but the difference between the groups was not statistically significant considering the frequency and amplitude of the epileptiform activity.
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Sonuç & Katkı:Since moderate doses of these vitamins have no side effects, it might be a good idea to use them with NMDA blockers to provide an earlier antiepileptic effect.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Key words: Experimental epilepsy · NMDA · memantine

Özet

To evaluate the effects of coadministration of vitamins alpha-tocopherol, ascorbic acid, and pyridoxine with memantine on a penicillin-induced experimental epilepsy model in rats so as to clarify the eventual interaction between these vitamins and the N-methyl-D-aspartate (NMDA) system. Materials and methods: The epileptic focus was produced by intracortical penicillin G potassium injection. The effects of intraperitoneal injections of memantine, memantine + alpha-tocopherol, memantine + ascorbic acid, and memantine + pyridoxine combinations on epileptiform activity were evaluated in electrocorticogram recordings. Results: The antiepileptiform effects appeared earlier in all memantine and vitamin coadministrated groups compared to the memantine-alone group, but the difference between the groups was not statistically significant considering the frequency and amplitude of the epileptiform activity. Conclusion: Coadministration of vitamins does not enhance the antiepileptiform activity of memantine in penicillin-induced epilepsy in rats. However, this coadministration causes the earlier appearance of antiseizure effects. Since moderate doses of these vitamins have no side effects, it might be a good idea to use them with NMDA blockers to provide an earlier antiepileptic effect.

Abstract

To evaluate the effects of coadministration of vitamins alpha-tocopherol, ascorbic acid, and pyridoxine with memantine on a penicillin-induced experimental epilepsy model in rats so as to clarify the eventual interaction between these vitamins and the N-methyl-D-aspartate (NMDA) system. Materials and methods: The epileptic focus was produced by intracortical penicillin G potassium injection. The effects of intraperitoneal injections of memantine, memantine + alpha-tocopherol, memantine + ascorbic acid, and memantine + pyridoxine combinations on epileptiform activity were evaluated in electrocorticogram recordings. Results: The antiepileptiform effects appeared earlier in all memantine and vitamin coadministrated groups compared to the memantine-alone group, but the difference between the groups was not statistically significant considering the frequency and amplitude of the epileptiform activity. Conclusion: Coadministration of vitamins does not enhance the antiepileptiform activity of memantine in penicillin-induced epilepsy in rats. However, this coadministration causes the earlier appearance of antiseizure effects. Since moderate doses of these vitamins have no side effects, it might be a good idea to use them with NMDA blockers to provide an earlier antiepileptic effect.

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Bu Makaleye Atıf Yap

YILDIRIM, M., AYYILDIZ, M., AĞAR, E., AYDIN, D. (2022). The effect of combined treatment of alpha-tocopherol, ascorbic acid, and pyridoxine with NMDA blocker memantine on penicillin-induced epileptiform activity in rats. Turkish Journal of Medical Sciences, Cilt: 43 - Sayı: 2, 245–250. https://ajindex.com/articles/611124

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Kaynakça (13)

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