KaydedilenlerDerginizi ekleyin

Dergiler / Turkish Journal of Medical Sciences / 2013 / Cilt: 43 - Sayı: 1

Investigation of the protective effects of L-carnitine and L-arginine on cardiovascular changes induced by ACTH and dexamethasone in rabbits

Metehan UZUN
Birkan TOPÇU
Sayfa
168–173
Yayın Tarihi
2022-11-04
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: Application of ACTH results in prolongation of QT and QTc intervals and increases in CK-MB and TnI levels, which are indicators of heart muscle damage.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:To determine the protective effects of L-carnitine on cardiovascular changes that may occur in rabbits treated with adrenocorticotropic hormone (ACTH) and dexamethasone (DEX).
📊
Temel Bulgular & Veri:Materials and methods: Rabbits of equal weight were divided into 7 groups with 6 animals in each.
💡
Sonuç & Katkı:Conclusion: Application of ACTH results in prolongation of QT and QTc intervals and increases in CK-MB and TnI levels, which are indicators of heart muscle damage.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Key words: Nitric oxide · CK-MB · troponin

Özet

To determine the protective effects of L-carnitine on cardiovascular changes that may occur in rabbits treated with adrenocorticotropic hormone (ACTH) and dexamethasone (DEX). Materials and methods: Rabbits of equal weight were divided into 7 groups with 6 animals in each. Blood samples were collected from all groups on days 1, 7, and 14, and blood pressure values and ECG monitoring were recorded. Nitric oxide (NO), creatine kinase MB (CK-MB), and troponin I (TnI) levels were determined in blood samples. Heart rate, QT, and corrected QT (QTc) values were calculated from ECG records. Results: The QT and QTc times were prolonged significantly (P < 0.001) in the ACTH-treated groups compared to the control group, and L-carnitine had no protective effect. Moreover, CK-MB (P < 0.05) and TnI (P < 0.001) levels were higher in the ACTH-treated groups than they were in the control group. Conclusion: Application of ACTH results in prolongation of QT and QTc intervals and increases in CK-MB and TnI levels, which are indicators of heart muscle damage.

Abstract

To determine the protective effects of L-carnitine on cardiovascular changes that may occur in rabbits treated with adrenocorticotropic hormone (ACTH) and dexamethasone (DEX). Materials and methods: Rabbits of equal weight were divided into 7 groups with 6 animals in each. Blood samples were collected from all groups on days 1, 7, and 14, and blood pressure values and ECG monitoring were recorded. Nitric oxide (NO), creatine kinase MB (CK-MB), and troponin I (TnI) levels were determined in blood samples. Heart rate, QT, and corrected QT (QTc) values were calculated from ECG records. Results: The QT and QTc times were prolonged significantly (P < 0.001) in the ACTH-treated groups compared to the control group, and L-carnitine had no protective effect. Moreover, CK-MB (P < 0.05) and TnI (P < 0.001) levels were higher in the ACTH-treated groups than they were in the control group. Conclusion: Application of ACTH results in prolongation of QT and QTc intervals and increases in CK-MB and TnI levels, which are indicators of heart muscle damage.

🔖

Bu Makaleye Atıf Yap

UZUN, M., TOPÇU, B. (2022). Investigation of the protective effects of L-carnitine and L-arginine on cardiovascular changes induced by ACTH and dexamethasone in rabbits. Turkish Journal of Medical Sciences, Cilt: 43 - Sayı: 1, 168–173. https://ajindex.com/articles/611031

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (12)

  1. Kop WJ. Acute and chronic psychological risk factors for coronary syndromes: moderating effects of coronary artery disease severity. J Psychosom Res 1997; 43: 167–81. Nemeroff CB. New vistas in neuropeptide research in neuropsychiatry: focus on corticotropin-releasing factor. Neuropsychopharmacology 1992; 6: 69–75.
  2. Narin F, Narin N, Başarslan F, Baykan A, Sezer S, Akgün H et al. The effect of L-tryptophan on the heart in rabbits via chronic hypoxia. Turk J Med Sci 2010; 40: 257–263.
  3. Uzun M, Yapar K, Uzlu E, Çitil M, Erdoğan HM. QT interval prolongation and decreased heart rates after intravenous bolus oxytocin injection in male and female conscious rabbits. Gen Physiol Biophys 2007; 26: 168–72. Fridericia LS. Die Systolendauer im Elektrokardiogramm bei normalen Menschen und bei Herzkranken. Acta Med Scand 1920; 53, 469–86.
  4. Ypsilantis P, Didilis VN, Politou M, Bougioukas I, Bougioukas G, Simopoulos C. A comparative study of invasive and oscillometric methods of arterial blood pressure measurement in the anesthetized rabbit. Res Vet Sci 2005; 78: 269–75.
  5. Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 2001; 5: 62–71. Cubeddu LX. QT prolongation and fatal arrhythmias: a review of clinical implications and effects of drugs. Am J Ther 2003; 10: 452–7.
  6. Horvarth G, Racker FK, Goldberger JJ, Johnson B, Jain S, Kadish AH. Electrophysiological and anatomic heterogeneity in evolving canine myocardial infarction. Pacing Clin Electrophysiol 2000; 23: 1068–79.
  7. Beyazit Y, Güven GS, İskit AB. Uzun QT sendromu. Hacettepe Tıp Dergisi 2005; 36: 43–48.
  8. Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001; 357: 593– 615. Cotton JM, Kearney MT, Shah AM. Nitric oxide and myocardial function in heart failure: friend or foe? Heart 2002; 88: 564–6.
  9. Chowdhary S, Nuttall SL, Coote JH, Townend JN. L-Arginine augments cardiac vagal control in healthy human subjects. Hypertension 2002; 39: 51–56.
  10. Chowdhary S, Harrington D, Bonser RS, Coote JH, Townend JN. Chronotropic effects of nitric oxide in the denervated human heart. J Physiol 2002; 541: 645–51.
  11. Turner SW, Wen CH, Li M, Whitworth JA. L-Arginine prevents corticotropin- induced increases in blood pressure in the rat. Hypertension 1996; 27: 184–8.
  12. Wang J, Brown MA, Tam SH, Chen MC, Whitworth JA. The effects of diet on measurement of nitric oxide metabolites. Clin Exp Pharmacol Physiol 1997;