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Dergiler / Turkish Journal of Medical Sciences / 2016 / Cilt: 46 - Sayı: 1

The relation between serum cathepsin D level and carotid intima-media thickness in nondiabetic hypertensive patients

Fatih DEDE
İhsan ATEŞ
Nihal ÖZKAYAR
Turan TURHAN
Ayşe Nurdan BARÇA
Fatma AKYEL
Serhan Vahit PİŞKİNPAŞA
Sayfa
13–17
Yayın Tarihi
2022-11-05
DOI
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Conclusions: Increased serum cathepsin D level was found to be associated with CIMT in nondiabetic hypertensive patients.

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Amaç & Hipotez:Background/aim: We aimed to investigate the relation between carotid intima-media thickness (CIMT) and serum cathepsin D level in hypertensive patients.
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Temel Bulgular & Veri:Materials and methods: This was a cross-sectional study of 74 hypertensive patients (22 males and 52 females, with a mean age of 51.86 ± 11.75 years).
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Sonuç & Katkı:Conclusions: Increased serum cathepsin D level was found to be associated with CIMT in nondiabetic hypertensive patients.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Background/aim: We aimed to investigate the relation between carotid intima-media thickness (CIMT) and serum cathepsin D level in hypertensive patients. Materials and methods: This was a cross-sectional study of 74 hypertensive patients (22 males and 52 females, with a mean age of 51.86 ± 11.75 years). Serum levels of cathepsin D were measured with an enzyme-linked immunosorbent assay. CIMT measurements were taken from 3 different points: right and left common carotid arteries, bifurcation, and the first 2 cm of the internal carotid artery. Mean CIMT was calculated by averaging the measurements taken 3 times from each carotid artery. Results: Mean CIMT value was 0.76 ± 0.15 mm, and median cathepsin D level was 190.3 (12.8 2681.3) ng/mL. A marked positive correlation was found between cathepsin D levels and CIMT (r = 0.331, P = 0.04). In multivariate linear regression analysis, cathepsin D, albumin levels, and the duration of hypertension were significant predictors of CIMT (P = 0.017, P = 0.008, and P = 0.043, respectively). Conclusions: Increased serum cathepsin D level was found to be associated with CIMT in nondiabetic hypertensive patients.

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Bu Makaleye Atıf Yap

DEDE, F., ATEŞ, İ., ÖZKAYAR, N., TURHAN, T., BARÇA, A. N., AKYEL, F., PİŞKİNPAŞA, S. V. (2022). The relation between serum cathepsin D level and carotid intima-media thickness in nondiabetic hypertensive patients. Turkish Journal of Medical Sciences, Cilt: 46 - Sayı: 1, 13–17. https://ajindex.com/articles/610885

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Kaynakça (13)

  1. Kannel WB. Office assessment of coronary candidates and risk factor insights from the Framingham study. J Hypertens Suppl 1991; 9: 13–19
  2. Kannel WB. Hypertension as a risk factor for cardiac events— epidemiologic results of long-term studies. J Cardiovasc Pharm 1993; 21: 27–37
  3. Mente A, Yusuf S, Islam S, McQueen MJ, Tanomsup S, Onen CL, Rangarajan S, Gerstein HC, Anand SS; INTERHEART Investigators. Metabolic syndrome and risk of acute myocardial infarction a case-control study of 26,903 subjects from 52 countries. J Am Coll Cardiol 2010; 55: 2390–2398
  4. Mallika V, Goswami B, Rajappa M. Atherosclerosis pathophysiology and the role of novel risk factors: a clinicobiochemical perspective. Angiology 2007; 58: 513–522
  5. Alexander RW. Hypertension and the pathogenesis of atherosclerosis. Oxidative stress and the mediation of arterial inflammatory response: a new perspective. Hypertension 1995; 25: 155–161
  6. Aminbakhsh A, Mancini GBJ. Carotid intima-media thickness measurements: what defines an abnormality? A systematic review. Clin Invest Med 1999; 22: 149–157
  7. Burke GL, Evans GW, Riley WA, Sharrett AR, Howard G, Barnes RW, Rosamond W, Crow RS, Rautaharju PM, Heiss G. Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults. Stroke 1995; 26: 386–391
  8. Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 2007; 115: 459–467
  9. Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR, Clegg LX. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993. Am J Epidemiol 1997; 146: 483–494
  10. Benes P, Vetvicka V, Fusek M. Cathepsin D—many functions of one aspartic protease. Crit Rev Oncol Hematol 2008; 68: 12–28
  11. Duran MC, Martin-Ventura JL, Mohammed S, Barderas MG, Blanco-Colio LM, Mas S, Moral V, Ortega L, Tuñón J, Jensen ON et al. Atorvastatin modulates the profile of proteins released by human atherosclerotic plaques. Eur J Pharmacol 2007; 562: 119–129
  12. Vivanco F, Padial LR, Darde VM, de la Cuesta F, AlvarezLlamas G, Diaz-Prieto N, Barderas MG. Proteomic biomarkers of atherosclerosis. Biomark Insights 2008; 3: 101–113
  13. Liu J, Sukhova GK, Sun JS, Xu WH, Libby P, Shi GP. Lysosomal cysteine proteases in atherosclerosis. Arterioscl Throm Vas