KaydedilenlerDerginizi ekleyin

Dergiler / Turkish Journal of Medical Sciences / 2016 / Cilt: 46 - Sayı: 1

Genotypes and virulence factors of Candida species isolated from oralcavities of patients with type 2 diabetes mellitus

Ayşe Nedret KOÇ
Halit DİRİ
ARSLAN Soley
Hafize SAV
Fatih TANRIVERDİ
Gonca AYDEMİR
Ahmet Ercan ŞEKERCİ
Sayfa
18–27
Yayın Tarihi
2022-11-05
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Different genotypes of Candida albicans exhibited different virulence activities.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Background/aim: This study compared the genotypes and virulence factors of Candida species isolated from oral cavities of healthy individuals and patients with diabetes mellitus (DM).
📊
Temel Bulgular & Veri:Materials and methods: A total of 142 healthy individuals and 73 diabetic patients participated in this study.
💡
Sonuç & Katkı:Different genotypes of Candida albicans exhibited different virulence activities.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Background/aim: This study compared the genotypes and virulence factors of Candida species isolated from oral cavities of healthy individuals and patients with diabetes mellitus (DM). Materials and methods: A total of 142 healthy individuals and 73 diabetic patients participated in this study. Study populations were classified into 4 groups as follows: Group IHealthy, without caries; Group IIHealthy, with caries; Group IIIDM, with caries; Group IVDM, without caries. Diabetic patients blood glucose and hemoglobin A1c concentrations were determined. Identification of Candida species was performed with conventional methods. Biofilm production, proteinase, phospholipase, and esterase were analyzed. The genetic diversity of Candida species was established using rep-PCR. Results: The most isolated species was Candida albicans. There were statistical differences in terms of isolated Candida frequency between healthy subjects and diabetic patients. There was no statistical difference between the virulence factors of groups. Twelve genotypes were determined. While there were statistical differences in aerobe biofilm production, proteinase, and phospholipase activity between genotypes, there were no statistical differences in anaerobe biofilm production and esterase activity between genotypes. Conclusion: Diabetes has no effect on the activities of virulence factors of Candida species. Different genotypes of Candida albicans exhibited different virulence activities.

🔖

Bu Makaleye Atıf Yap

KOÇ, A. N., DİRİ, H., Soley, A., SAV, H., TANRIVERDİ, F., AYDEMİR, G., ŞEKERCİ, A. E. (2022). Genotypes and virulence factors of Candida species isolated from oralcavities of patients with type 2 diabetes mellitus. Turkish Journal of Medical Sciences, Cilt: 46 - Sayı: 1, 18–27. https://ajindex.com/articles/610859

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (16)

  1. Wang J, Ohshima T, Yasunari U, Namikoshi S, Yoshihara A, Miyazaki H, Maeda N. The carriage of Candida species on the dorsal surface of the tongue: the correlation with the dental, periodontal and prosthetic status in elderly subjects. Gerodontology 2006; 23: 157–163
  2. Rindum JL, Stenderup A, Holmstrup P. Identification of Candida albicans types related to healthy and pathological oral mucosa. J Oral Pathol Med 1994; 23: 406–412
  3. Beighton D, Brailsford S, Samaranayake LP, Brown JP, Ping FX, Grant-Mills D, Harris R, Lo EC, Naidoo S, Ramos-Gomez F et al. A multi-country comparison of caries-associated microflora in demographically diverse children. Community Dent Healthy 2004; 21 (Suppl. 1): 96–101
  4. Gabris K, Nagy G, Madlena M, Denes Z, Marton S, Keszthelyi G, Banoczy J. Associations between microbiological and salivary caries activity tests and caries experience in Hungarian adolescents. Caries Res 1999; 33: 191–195
  5. Manfredi M, McCullough MJ, Vescovi P, Al-Kaarawi ZM, Poster SR. Update on diabetes mellitus and related oral diseases. Oral Dis 2004; 10: 187–200
  6. Vernillo AT. Diabetes mellitus: relevance to dental treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 91: 263–270
  7. Ruechel R. Virulence factors of Candida species. In: Samaranayake LP, Macfarlane TW, editors. Oral Candidosis. London, UK: Wright Publishers; 1990. pp. 47–65
  8. Ramega G. Forging a link between biofilms and disease. Science 1999; 283: 1837–1839
  9. İnci M, Atalay MA, Koç AN, Evirgen Ö, Durmaz S, Demir G. Investigating virulence factors of clinical Candida isolates in relation to atmospheric conditions and genotype. Turk J Med Sci 2012; 42 (Suppl. 2): 1476–1483
  10. Ghannoum MA, Abu Elteen KH. Pathogenicity determinations of Candida. Mycoses 1990; 33: 265–282
  11. Perfect JR. Fungal virulence genes as targets for antifungal chemotherapy. Antimicrob Agents Chemother 1996; 40: 1577– 1583
  12. Pfaller M, Wenzel R. Impact of the changing epidemiology of fungal infections in the 1990s. Eur J Clin Microbiol Infect Dis 1992; 11: 287–291
  13. Banno Y, Yamada T, Nozawa Y. Secreted phospholipases of the dimorphic fungus, Candida albicans; separation of three enzymes and some biological properties. Sabouraudia 1985; 23: 47–54
  14. Hube B. Candida albicans secreted aspartyl proteinases. Curr Top Med Mycal 1996; 7: 55–56
  15. Schaller M, Borelli C, Korting HC, Hube B. Hydrolytic enzymes as virulence factors of Candida albicans. Mycoses 2005; 48: 365–377
  16. Sardi J