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Dergiler / Turkish Journal of Medical Sciences / 2017 / Cilt: 47 - Sayı: 2

Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma

Şenay AKIN
Gürhan DÖNMEZ
Gülriz ERİŞGEN
Burkay UTKU
Mahmut Nedim DORAL
Feza KORKUSUZ
Haydar Ali DEMİREL
Sayfa
570–576
Yayın Tarihi
2022-11-05
DOI
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Conclusion: Diclofenac, meloxicam, and acetylsalicylic acid did not affect PDGF-AB and VEGF serum levels.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background/aim: Platelet-rich plasma (PRP) application has gained widespread interest for musculoskeletal injuries.
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Temel Bulgular & Veri:Materials and methods: Two different final concentrations of diclofenac (0.5 µg mL 1 and 2.5 µg mL 1), meloxicam (0.8 µg mL 1 and 2.0 µg mL 1), and acetylsalicylic acid (final concentration 450 µm) were obtained in separate tubes with PRPs prepared from 20 healthy male volunteers.
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Sonuç & Katkı:Conclusion: Diclofenac, meloxicam, and acetylsalicylic acid did not affect PDGF-AB and VEGF serum levels.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Background/aim: Platelet-rich plasma (PRP) application has gained widespread interest for musculoskeletal injuries. Nonsteroidal antiinflammatory drugs are frequently used in sports medicine before and/or after PRP application. Our study seeks to determine whether serum levels of platelet-derived growth factor-AB (PDGF-AB) and vascular endothelial growth factor (VEGF) levels of PRP would be affected by nonsteroidal antiinflammatory drugs. Materials and methods: Two different final concentrations of diclofenac (0.5 µg mL 1 and 2.5 µg mL 1), meloxicam (0.8 µg mL 1 and 2.0 µg mL 1), and acetylsalicylic acid (final concentration 450 µm) were obtained in separate tubes with PRPs prepared from 20 healthy male volunteers. Medicine-free PRP was the control group. Growth factors were measured using ELISA. Results: PDGF-AB and VEGF serum levels did not change with diclofenac, meloxicam, or acetylsalicylic acid addition. PDGF-AB and VEGF serum levels correlated with each other. Conclusion: Diclofenac, meloxicam, and acetylsalicylic acid did not affect PDGF-AB and VEGF serum levels.

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Bu Makaleye Atıf Yap

AKIN, Ş., DÖNMEZ, G., ERİŞGEN, G., UTKU, B., DORAL, M. N., KORKUSUZ, F., DEMİREL, H. A. (2022). Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma. Turkish Journal of Medical Sciences, Cilt: 47 - Sayı: 2, 570–576. https://ajindex.com/articles/610580

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Kaynakça (12)

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