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Dergiler / Turkish Journal of Medical Sciences / 2018 / Cilt: 48 - Sayı: 6

Vascular responses of aortic, renal, and uterine arteries in suramin-induced preeclampsia-like syndrome in rats

Meral TUNCER
Edip Güvenç ÇEKİÇ
Güray SOYDAN
Dilek ERTOY BAYDAR
Sebile GÜLER ÇEKİÇ
Sayfa
1328–1339
Yayın Tarihi
2022-11-05
DOI
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In this study, weshowed that preeclampsia-like syndrome occurred in suramin-given rats.Conclusion: Our findings, which show that endothelial dysfunction occurred in uterine and renal arteries but not in the aorta, areconsistent with the human findings of microvascular changes in preeclampsia.

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Amaç & Hipotez:Background/aim: Suramin is a potent angiogenesis inhibitor in rodents and attenuates placental development in rat pregnancy.
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Temel Bulgular & Veri:Weaimed to produce preeclampsia-like syndrome by suramin administration in rats and to investigate the functional responses in aortic,renal, and uterine arteries.Materials and methods: Pregnant and nonpregnant wistar rats received suramin (100 mg/kg, intraperitoneal) or equal volume of salineon days 10 and 11.
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Sonuç & Katkı:In this study, weshowed that preeclampsia-like syndrome occurred in suramin-given rats.Conclusion: Our findings, which show that endothelial dysfunction occurred in uterine and renal arteries but not in the aorta, areconsistent with the human findings of microvascular changes in preeclampsia.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Background/aim: Suramin is a potent angiogenesis inhibitor in rodents and attenuates placental development in rat pregnancy. Weaimed to produce preeclampsia-like syndrome by suramin administration in rats and to investigate the functional responses in aortic,renal, and uterine arteries.Materials and methods: Pregnant and nonpregnant wistar rats received suramin (100 mg/kg, intraperitoneal) or equal volume of salineon days 10 and 11. Blood pressures of rats were observed daily. On the day 20, rats were executed. Protein levels in urine were measuredand fetuses, placentas, and kidneys were weighted and evaluated. Thoracic aorta, renal, and uterine arteries were removed for functionalstudies.Results: Increased blood pressures and proteinuria were detected in suramin-given pregnant rats. Pathological examination of kidneysshowed an acute tubular injury after suramin injection. Numbers and weights of fetuses and placentas were reduced in suramin-givenpregnant rats. In functional studies, endothelial dysfunction occurred in uterine and renal arteries but not in the aorta. In this study, weshowed that preeclampsia-like syndrome occurred in suramin-given rats.Conclusion: Our findings, which show that endothelial dysfunction occurred in uterine and renal arteries but not in the aorta, areconsistent with the human findings of microvascular changes in preeclampsia.

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Bu Makaleye Atıf Yap

TUNCER, M., ÇEKİÇ, E. G., SOYDAN, G., BAYDAR, D. E., ÇEKİÇ, S. G. (2022). Vascular responses of aortic, renal, and uterine arteries in suramin-induced preeclampsia-like syndrome in rats. Turkish Journal of Medical Sciences, Cilt: 48 - Sayı: 6, 1328–1339. https://ajindex.com/articles/610339

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Kaynakça (13)

  1. Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Kirmeyer S. Births: final data for 2004. Natl Vital Stat Rep 2006; 55: 1-101.
  2. Ghulmiyyah L, Sibai B. Maternal mortality from preeclampsia/ eclampsia. Semin Perinatol 2012; 36: 56-59.
  3. Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science 2005; 308: 1592-1594.
  4. McNally R, Alqudah A, Obradovic D, McClements L. Elucidating the pathogenesis of pre-eclampsia using in vitro models of spiral uterine artery remodelling. Curr Hypertens Rep 2017; 19: 93. Brosens IA, Robertson WB, Dixon HG. The role of the spiral arteries in the pathogenesis of preeclampsia. Obs Gynecol Annu 1972; 1: 177-191. Redman CW. Current topic: pre-eclampsia and the placenta. Placenta 1991; 12: 301-308.
  5. Roberts JM, Taylor RN, Goldfien A. Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia. Am J Hypertens 1991; 4: 700-708.
  6. Redman CW, Sargent IL. Pre-eclampsia, the placenta and the maternal systemic inflammatory response—a review. Placenta 2003; 24 Suppl A: 21-27.
  7. Maynard S, Epstein FH, Karumanchi SA. Preeclampsia and angiogenic imbalance. Annu Rev Med 2008; 59: 61-78.
  8. Visser W, Wallenburg HC. Central hemodynamic observations in untreated preeclamptic patients. Hypertension 1991; 17: 1072-1077.
  9. Pijnenborg R, Anthony J, Davey DA, Rees A, Tiltman A, Vercruysse L, van Assche A. Placental bed spiral arteries in the hypertensive disorders of pregnancy. Br J Obs Gynaecol 1991; 98: 648-655.
  10. Dechend R, Luft FC. Angiogenesis factors and preeclampsia. Nat Med 2008; 14: 1187-1188.
  11. Verdonk K, Saleh L, Lankhorst S, Smilde JEI, van Ingen MM, Garrelds IM, Friesema EC, Russcheret H, van den Meiracker AH, Visser W et al. Association studies suggest a key role for endothelin-1 in the pathogenesis of preeclampsia and the accompanying renin-angiotensin-aldosterone system suppression. Hypertension 2015; 65: 1316-1323. Jankowski M. Angiogenesis inhibition and preeclampsia. J Hypertens 2009; 27: 707-708.
  12. Carlström M, Wentzel P, Skøtt O, Persson AE, Eriksson UJ. Angiogenesis inhibition causes hypertension and placental dysfunction in a rat model of preeclampsia. J Hypertens 2009; 27: 829-837.
  13. Nash P, Wentzel P, Lindeberg S, Naessen T, Jansson L, Olovsson M, Eriksson UJ. Placental dysfunction in suramin-treated rats–a new model for pre-eclampsia. Placenta 2005; 26: 410- 418. Bocci G, Danesi R, Benelli U, Innocenti F, Di Paolo A, Fogli S, Del Tacca M. Inhibitory effect of suramin in rat mo