Low levels of vitamin D are associated with nosocomial infections but not with short-term mortality in critically ill patients

Only the 1-year mortality rate was significantly higheramong patients with 25 (OH) D levels less than 20 ng/mL.Conclusion: Low vitamin D levels are significantly associated with ICU-related infections but not with ICU or hospital mortality.However, further studies are needed to identify the role of vitamin D deficiency in predicting ICU outcomes.

📌 3 Maddede Bu Makale

🎯

Amaç & Hipotez:Background/aim: A prospective observational study was conducted to determine the relationship between vitamin D deficiency andnosocomial infections among intensive care unit (ICU) patients.Materials and methods: Demographic data, season of admission, vitamin D levels at admission, premorbid lifestyle scores, comorbidconditions, and admission diagnosis were recorded in 306 ICU patients.

📊

Temel Bulgular & Veri:Infections that developed at least 48 h after admission tothe ICU were the primary outcome, and ICU, hospital, and 1-year mortality were the secondary outcomes.

💡

Sonuç & Katkı:Only the 1-year mortality rate was significantly higheramong patients with 25 (OH) D levels less than 20 ng/mL.Conclusion: Low vitamin D levels are significantly associated with ICU-related infections but not with ICU or hospital mortality.However, further studies are needed to identify the role of vitamin D deficiency in predicting ICU outcomes.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Abstract

Background/aim: A prospective observational study was conducted to determine the relationship between vitamin D deficiency andnosocomial infections among intensive care unit (ICU) patients.Materials and methods: Demographic data, season of admission, vitamin D levels at admission, premorbid lifestyle scores, comorbidconditions, and admission diagnosis were recorded in 306 ICU patients. Infections that developed at least 48 h after admission tothe ICU were the primary outcome, and ICU, hospital, and 1-year mortality were the secondary outcomes. Infections were evaluatedfor 28 days, and for the entire duration of ICU stay independently. Multiple logistic regression analysis was performed to control forconfounding factors that were statistically significant in univariate analysis.Results: All infection and mortality rates were significantly higher in low 25 (OH) D groups in univariate analysis. After adjusting forconfounding factors, infection rates remained higher in the deficient group. However, ICU and hospital mortality did not show anystatistically significant difference between deficient and nondeficient groups. Only the 1-year mortality rate was significantly higheramong patients with 25 (OH) D levels less than 20 ng/mL.Conclusion: Low vitamin D levels are significantly associated with ICU-related infections but not with ICU or hospital mortality.However, further studies are needed to identify the role of vitamin D deficiency in predicting ICU outcomes.

🔖

Bu Makaleye Atıf Yap

ŞENOĞLU, N., KÖSE, Ş., KÖSE, I., ÇAKMAK, M., ZİNCİRCİOĞLU, Ç., ÖZKARAKAŞ, H., KUZUCU, L., ERSAN, G. (2022). Low levels of vitamin D are associated with nosocomial infections but not with short-term mortality in critically ill patients. Turkish Journal of Medical Sciences, Cilt: 48 - Sayı: 2, 324–331. https://ajindex.com/articles/610252

📄 Tam Metin PDF Okuyucu

Yeni Sekmede Aç ↗

↗Yeni Sekme

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (11)

Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, Moreno R, Lipman J, Gomersall C, Sakr Y et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA-J Am Med Assoc 2009; 302: 2323-2329.
Prowle JR, Echeverri JE, Ligabo EV, Sherry N, Taori GC, Crozier TM, Hart GK, Korman TM, Mayall BC, Johnson PD et al. Acquired bloodstream infection in the intensive care unit: incidence and attributable mortality. Crit Care 2011; 15: 100. Erbay H, Yalcin AN, Serin S, Turgut H, Tomatir E, Cetin B, Zencir M. Nosocomial infections in intensive care unit in a Turkish university hospital: a 2-year survey. Intens Care Med 2003; 29: 1482-1488.
Ben-Ami R, Rodríguez-Baño J, Arslan H, Pitout JD, Quentin C, Calbo ES, Azap OK, Arpin C, Pascual A, Livermore DM et al. A multinational survey of risk factors for infection with extendedspectrum beta-lactamase-producing Enterobacteriaceae in nonhospitalized patients. Clin Infect Dis 2009; 49: 682-690.
Safdar N, Maki DG. The commonality of risk factors for nosocomial colonization and infection with antimicrobialresistant Staphylococcus aureus, enterococcus, gram-negative bacilli, Clostridium difficile, and Candida. Ann Intern Med 2002; 136: 834-844.
Mora JR, Iwata M, von Andrian UH. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 2008; 8: 685-698.
Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endoc 2008; 4: 80-90.
Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E. Epidemic influenza and vitamin D. Epidemiol Infect 2006; 134: 1129-1140.
Wolpowitz D, Gilchrest BA. The vitamin D questions: how much do you need and how should you get it? J Am Acad Dermatol 2006; 54: 301-317.
Jeng L, Yamshchikov AV, Judd SE, Blumberg HM, Martin GS, Ziegler TR, Tangpricha V. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med 2009; 7: 28. Lee P, Eisman JA, Center JR. Vitamin D deficiency in critically ill patients. New Engl J Med 2009; 360: 1912-1914.
Lee P, Nair P, Eisman JA, Center JR. Vitamin D deficiency in the intensive care unit: an invisible accomplice to morbidity and mortality? Intens Care Med 2009; 35: 2028-2032.
Lucidarme O, Messai E, Mazzoni T, Arcade M, du Cheyron D. Incidence and risk factors of vitamin D deficiency in critically ill patients: resu