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AI InsightFollicular degeneration was significantly increased in Group 3.Conclusion: Exogenously administered melatonin, if used at much higher doses orally, may be a noncytotoxic, antiapoptotic agent andmay also have a protective effect on ovarian tissue damage that radiation can cause at the level of fine structure.
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Abstract
Objectives: We observed the efficacy of melatonin in preventing ovarian tissue damage in rats exposed to magnetic fields.Materials and methods: Forty rats were divided into four treatment groups: Group 1, control group (n = 10); Group 2, melatoninadministration only (n = 10); Group 3, magnetic field exposure only (n = 10); Group 4, magnetic field exposure with melatoninadministration (n = 10). The magnetic field was applied at a dose of 20 µT for 30 min/day for 10 days. Melatonin was orally administeredat a dose of 10 mg/kg. We evaluated follicle count, degree of fibrosis, amount of adhesion, amount of apoptosis, ovarian dimensions, andfollicular degeneration by dissecting the ovaries of the rats on day 11, and differences among the groups were evaluated.Results: Group 3 had an increased amount of follicle degeneration, more fibrosis, and more adhesion than Group 4, but these findingswere not statistically significant. The apoptosis scores in Groups 1 and 2 were significantly lower than in the other groups. Ovariandimensions were significantly decreased in Group 3. Follicular degeneration was significantly increased in Group 3.Conclusion: Exogenously administered melatonin, if used at much higher doses orally, may be a noncytotoxic, antiapoptotic agent andmay also have a protective effect on ovarian tissue damage that radiation can cause at the level of fine structure.