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Dergiler / Turkish Journal of Medical Sciences / 2018 / Cilt: 48 - Sayı: 1

Effects of cinnamic acid on complications of diabetes

Tuğbagül ÇAL
Merve BACANLI
Ayşe Nurşen BAŞARAN
Ülkü ÜNDEĞER BUCURGAT
Arif Ahmet BAŞARAN
Sevtap AYDIN
Hatice Gül ANLAR
Nuray ARI
Sayfa
168–177
Yayın Tarihi
2022-11-05
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

CAtreatment ameliorated these effects.Conclusion: It seems that CA might have a role in the prevention of the complications of diabetes.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background/aim: Diabetes mellitus (DM) is a major health problem worldwide.
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Temel Bulgular & Veri:Oxidativestress parameters such as catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidaseactivities and 8-hydroxy-2’-deoxyguanosine, total glutathione, and malondialdehyde levels; biochemical parameters including insulin,total bilirubin, and BCA protein levels; hepatic enzyme levels such as alanine aminotransferase, aspartate aminotransferase, alkalinephosphatase, and gamma-glutamyl transferase; and lipid profile parameters including high-density lipoprotein, low-density lipoprotein,total cholesterol, and triglyceride levels were also evaluated.Results: DM caused genotoxic damage and alterations in lipid profiles, oxidative stress parameters, and hepatic enzymes levels.
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Sonuç & Katkı:CAtreatment ameliorated these effects.Conclusion: It seems that CA might have a role in the prevention of the complications of diabetes.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Background/aim: Diabetes mellitus (DM) is a major health problem worldwide. Cinnamic acid (CA) and its derivatives are synthesizedin plants and increasing attention has been given to them in recent years due to the high number of beneficial health properties attributedto their consumption. The aim of this study was to investigate the effects of CA on streptozotocin-induced diabetes in Wistar albino rats.Materials and methods: DNA damage was evaluated in the blood, liver, and kidney cells of rats by the alkaline comet assay. Oxidativestress parameters such as catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidaseactivities and 8-hydroxy-2’-deoxyguanosine, total glutathione, and malondialdehyde levels; biochemical parameters including insulin,total bilirubin, and BCA protein levels; hepatic enzyme levels such as alanine aminotransferase, aspartate aminotransferase, alkalinephosphatase, and gamma-glutamyl transferase; and lipid profile parameters including high-density lipoprotein, low-density lipoprotein,total cholesterol, and triglyceride levels were also evaluated.Results: DM caused genotoxic damage and alterations in lipid profiles, oxidative stress parameters, and hepatic enzymes levels. CAtreatment ameliorated these effects.Conclusion: It seems that CA might have a role in the prevention of the complications of diabetes.

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Bu Makaleye Atıf Yap

ÇAL, T., BACANLI, M., BAŞARAN, A. N., BUCURGAT, Ü. Ü., BAŞARAN, A. A., AYDIN, S., ANLAR, H. G., ARI, N. (2022). Effects of cinnamic acid on complications of diabetes. Turkish Journal of Medical Sciences, Cilt: 48 - Sayı: 1, 168–177. https://ajindex.com/articles/610163

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