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Dergiler / Turkish Journal of Medical Sciences / 2019 / Cilt: 49 - Sayı: 6

Does mammalian target of rapamycin or sestrin 1 protein signaling have a role in bone fracture healing?

Özhan PAZARCI
Yalkın ÇAMURCU
Seyran KILINÇ
Halef Okan DOĞAN
Sayfa
1774–1778
Yayın Tarihi
2022-11-04
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This study may guide further clinical studies investigatingthe potential role of mTOR signaling in the bone healing process.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background/aim: Fracture healing is a complex physiological process that involves a well-orchestrated series of biological events.
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Temel Bulgular & Veri:Themammalian target of rapamycin (mTOR) and sestrin 1 (SESN 1) play a central role in cell metabolism, proliferation, and survival.
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Sonuç & Katkı:This study may guide further clinical studies investigatingthe potential role of mTOR signaling in the bone healing process.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Background/aim: Fracture healing is a complex physiological process that involves a well-orchestrated series of biological events. Themammalian target of rapamycin (mTOR) and sestrin 1 (SESN 1) play a central role in cell metabolism, proliferation, and survival. Theaim of our study is to present serum mTOR and SESN 1 levels by comparing patients with or without bone fractures. It is also a guidefor further research on the roles of these proteins in fracture healing.Materials and methods: A total of 34 patients (10 females, 24 males) with bone fractures and 32 controls (10 females, 22 males)participated in this study. After collecting serum venous blood samples, the quantitative sandwich ELISA technique was used for thedetermination of serum mTOR and SESN 1 levels.Results: The mean serum mTOR level was significantly higher in the fracture group compared to the control group (P = 0.001). However,SESN 1 levels did not significantly differ between groups (P = 0.913).Conclusion: We found that serum mTOR levels increased on the first day after fracture compared to the control group. However, weobtained no significant difference between groups in terms of SESN 1 levels. This study may guide further clinical studies investigatingthe potential role of mTOR signaling in the bone healing process.

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Bu Makaleye Atıf Yap

PAZARCI, Ö., ÇAMURCU, Y., KILINÇ, S., DOĞAN, H. O. (2022). Does mammalian target of rapamycin or sestrin 1 protein signaling have a role in bone fracture healing?. Turkish Journal of Medical Sciences, Cilt: 49 - Sayı: 6, 1774–1778. https://ajindex.com/articles/610100

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Kaynakça (13)

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