Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightPre-operative/post-operative AMH decreases were statistically significant in negative direction in the detorsion onlygroup when compared to the metformin+detorsion and control groups (P = 0.001).Conclusion: Metformin+detorsion treatment may be effective in protecting the ovarian reserve after ovarian torsion.
📌 3 Maddede Bu Makale
Abstract
Background/aim: Adnexal torsion is a common gynaecological emergency, and considered to be a problem mostly in reproductive-agewomen. To evaluate the effect of metformin and detorsion treatment on reducing ovarian reserve in an ovarian torsion model.Materials and methods: Twenty-four nonpregnant, Wistar Hannover rats were included in the study. Animals were divided into 3groups: the control group, the detorsion only group, and the metformin + detorsion group. The first group received only laparotomy.In the second group, ovaries were fixed to the abdominal wall after performing 360° ovarian torsion, followed by detorsion after a 3-hperiod of ischemia. The third group underwent the same torsion and detorsion procedures as the second group, and received 50 mg/kgmetformin by gavage for 14 days. Ovarian damage scores, follicle counts, and AMH levels were evaluated.Results: The total damage score was significantly increased in the detorsion only group compared to the metformin+detorsion andcontrol groups. Pre-operative/post-operative AMH decreases were statistically significant in negative direction in the detorsion onlygroup when compared to the metformin+detorsion and control groups (P = 0.001).Conclusion: Metformin+detorsion treatment may be effective in protecting the ovarian reserve after ovarian torsion.