KaydedilenlerDerginizi ekleyin

Dergiler / Turkish Journal of Medical Sciences / 2021 / Cilt: 51 - Sayı: 5

The role of circadian rhythm in the regulation of cellular protein profiles in the brain

Mustafa Çağlar BEKER
Ertuğrul KILIÇ
Sayfa
2705–2715
Yayın Tarihi
2022-11-06
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: Taken together, here we identified circadian rhythm-related proteins, and our further analysis revealed that these proteins play significant roles in molecular function, membrane trafficking, biogenesis, cellular process, metabolic process, and neurodegenerative disorders such as Parkinson’s disease.Key words: Circadian rhythm, lc-ms/ms, PDE10A, proteomics, zeitgeber time

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Background/aim: Circadian rhythm plays a significant role in the regulation of almost all kinds of physiological processes.
📊
Temel Bulgular & Veri:Materials and methods: To identify the light and dark regulated proteins, 8–12 weeks, male Balb/C mice were used at two different time points (morning (Zeitgeber time-0 (ZT0)) and midnight (ZT18)) under physiological conditions.
💡
Sonuç & Katkı:Conclusion: Taken together, here we identified circadian rhythm-related proteins, and our further analysis revealed that these proteins play significant roles in molecular function, membrane trafficking, biogenesis, cellular process, metabolic process, and neurodegenerative disorders such as Parkinson’s disease.Key words: Circadian rhythm, lc-ms/ms, PDE10A, proteomics, zeitgeber time
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Background/aim: Circadian rhythm plays a significant role in the regulation of almost all kinds of physiological processes. In addition, it may also have a direct or indirect effect on the neurodegenerative processes, including Alzheimer’s disease, Parkinson’s disease, and ischemic stroke. Therefore, the identification of circadian rhythm-related proteins is crucial to be able to understand the molecular mechanism of the circadian rhythm and to define new therapeutic target for the treatment of degenerative disorders. Materials and methods: To identify the light and dark regulated proteins, 8–12 weeks, male Balb/C mice were used at two different time points (morning (Zeitgeber time-0 (ZT0)) and midnight (ZT18)) under physiological conditions. Therefore, brain tissues were analyzed via liquid chromatography tandem mass spectrometry. Results: A total of 1621 different proteins were identified between ZT0 and ZT18 mice. Among these proteins, 23 proteins were differentially expressed (p < 0.05 and fold change 1.4) in ZT18 mice, 11 upregulated (AKAP10, ALDOC, BLK, NCALD, NFL, PDE10A, PICAL, PSMB6, RL10, SH3L3, and SYNJ1), and 12 downregulated (AT2A2, AT2B1, CPNE5, KAP3, MAON, NPM, PI51C, PPR1B, SAM50, TOM70, TY3H, and VAPA) as compared with ZT0 mice. Conclusion: Taken together, here we identified circadian rhythm-related proteins, and our further analysis revealed that these proteins play significant roles in molecular function, membrane trafficking, biogenesis, cellular process, metabolic process, and neurodegenerative disorders such as Parkinson’s disease.Key words: Circadian rhythm, lc-ms/ms, PDE10A, proteomics, zeitgeber time

🔖

Bu Makaleye Atıf Yap

BEKER, M. Ç., KILIÇ, E. (2022). The role of circadian rhythm in the regulation of cellular protein profiles in the brain. Turkish Journal of Medical Sciences, Cilt: 51 - Sayı: 5, 2705–2715. https://ajindex.com/articles/609383

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (1)

  1. Xie Y, Tang Q, Chen G, Xie M, Yu S et al. New insights into the circadian rhythm and its related diseases. Frontiers in Physiology 2019; 10: 682. doi: 10.3389/fphys.2019.00682 2. Panda S, Hogenesch JB, Kay SA. Circadian rhythms from flies to human. Nature 2002; 417 (6886): 329-335. doi: 10.1038/417329a 3. Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature 2002; 418 (6901): 935-941. doi: 10.1038/nature00965 4. Hastings MH, Maywood ES, Brancaccio M. Generation of circadian rhythms in the suprachiasmatic nucleus. Nature Reviews Neuroscience 2018; 19 (8): 453-469. doi: 10.1038/s41583-018-0026-z 5. Patke A, Young MW, Axelrod S. Molecular mechanisms and physiological importance of circadian rhythms. Nature Reviews Molecular Cell Biology 2020; 21 (2): 67-84. doi: 10.1038/s41580-019-0179-2 6. Ripamonti L, Riva R, Maioli F, Zenesini C, Procaccianti G. Daily variation in the occurrence of different subtypes of stroke. Stroke Research and Treatment 2017; 2017: 9091250. doi: 10.1155/2017/9091250 7. Beker MC, Caglayan B, Yalcin E, Caglayan AB, Turkseven S et al. Time-of-day dependent neuronal injury after ischemic stroke: implication of circadian clock transcriptional factor Bmal1 and survival kinase AKT. Molecular Neurobiology 2018; 55 (3): 2565-2576. doi: 10.1007/s12035-017-0524-4 8. Hood S, Amir S. Neurodegeneration and the circadian clock. Frontiers in Aging Neuroscience 2017; 9: 170. doi: 10.3389/fnagi.2017.00170 9. Wisniewski JR, Zougman A, Nagaraj N, Mann M. Universal sample preparation method for proteome analysis. Nature Methods 2009; 6 (5): 359-362. doi: 10.1038/nmeth.1322 10. Yalcin E, Beker MC, Turkseven S, Caglayan B, Gurel B et al. Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival. Toxicology and Applied Pharmacology 2019; 379: 114686. doi: 10.1016/j.taap.2019.114686 11. Acioglu C, Mirabelli E, Baykal AT, Ni L, Ratnayake A et al. Toll like receptor 9 antagonism modulates spinal cord neuronal function and survival: direct versus astrocyte-mediated mechanisms. Brain, Behavior, and Immunity 2016; 56: 310- 324. doi: 10.1016/j.bbi.2016.03.027 12. Beker M, Caglayan AB, Beker MC, Altunay S, Karacay R et al. Lentivirally administered glial cell line-derived neurotrophic factor promotes post-ischemic neurological recovery, brain remodeling and contralesional pyramidal tract plasticity by regulating axonal growth inhibitors and guidance proteins. Experimental Neurology 2020; 331: 113364. doi: 10.101