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Dergiler / Turkish Journal of Biology / 2021 / Cilt: 45 - Sayı: 2

IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice

Deming LI
Ze WANG
Chunyan ZHANG
Cunshuan XU
Sayfa
225–234
Yayın Tarihi
2022-10-17
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Maintaining proper inflammation maycontribute to regeneration after liver partly surgical resection in the elderly.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Inflammation has a dual effect: it can protect the body and destroy tissue and cell as well.
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Temel Bulgular & Veri:The purpose of this experiment wasto determine the role of IL-1R1 in liver regeneration (LR) after partial hepatectomy (PH) in aged mice.
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Sonuç & Katkı:Maintaining proper inflammation maycontribute to regeneration after liver partly surgical resection in the elderly.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Inflammation has a dual effect: it can protect the body and destroy tissue and cell as well. The purpose of this experiment wasto determine the role of IL-1R1 in liver regeneration (LR) after partial hepatectomy (PH) in aged mice. The wild-type (WT, n = 36) andthe IL-1R1 knockout (KO, n = 36) 24-month-old C57BL/6J mice underwent two-thirds PH; 33 WT mice underwent sham operation.Liver coefficient was calculated by liver/body weight. The mRNA and protein expressions of genes were evaluated by quantitative realtime polymerase chain reaction (qRT-PCR) and Western blotting methods, respectively. Compared with WT mice, liver coefficient waslower in the IL-1R1 KO aged mice at 168 and 192 h (p = 0.039 and p = 0.027). The mRNA transcription of inflammation-related genesand cell cycle-associated genes decreased or delayed. The protein expressions of proliferation-related marker PCNA and proliferationassociated signaling pathway components JNK1, NF-κB and STAT3 reduced or retarded. There was stronger activation of proapoptoticproteins caspase-3, caspase-8 and BAX in the IL-1R1 KO mice at different time points (p < 0.05 or p < 0.01). IL-1R1 KO reducedinflammation and caused impaired liver regeneration after 2/3 partial hepatectomy in aged mice. Maintaining proper inflammation maycontribute to regeneration after liver partly surgical resection in the elderly.

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Bu Makaleye Atıf Yap

LI, D., WANG, Z., ZHANG, C., XU, C. (2022). IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice. Turkish Journal of Biology, Cilt: 45 - Sayı: 2, 225–234. https://ajindex.com/articles/600111

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Kaynakça (4)

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