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Dergiler / Turkish Journal of Biology / 2022 / Cilt: 46 - Sayı: 3

Point-of-care diagnosis of cervical cancer: potential protein biomarkers in cervicovaginal fluid

Özgüç TAKMAZ
Mete GÜNGÖR
Ahmet Tarık BAYKAL
Büşra KÖSE
Sayfa
195–206
Yayın Tarihi
2022-10-18
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In this article, POC screening tests and the studies of discovery of CVF protein biomarkers will be overviewed to consider the development of a method that can be used for the rapid and conceivable screening method of CxCa.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Cervical cancer (CxCa) is preventable and treatable via vaccination and screening.
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Temel Bulgular & Veri:Due to high false-negative result rates and low attendance of current expensive routine CxCa screening methods, it has become more important to develop a point-of-care (POC) screening method that every single woman could reach worldwide.
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Sonuç & Katkı:In this article, POC screening tests and the studies of discovery of CVF protein biomarkers will be overviewed to consider the development of a method that can be used for the rapid and conceivable screening method of CxCa.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Cervical cancer (CxCa) is preventable and treatable via vaccination and screening. Cervicovaginal fluid (CVF) represents the physiological components of the female genital tract. These components are suitable to be utilized for clinical purposes, therefore, making CVF a suitable material for disease screening approaches. Due to high false-negative result rates and low attendance of current expensive routine CxCa screening methods, it has become more important to develop a point-of-care (POC) screening method that every single woman could reach worldwide. For this purpose, various self-usage apparatus have been developed for screening of the human papilloma virus (HPV) infection. Furthermore, due to the low specificity of HPV tests and the high clearance rate of HPV infections, many patients undergo overtreatment. Since proteins play an important role in cellular process and carcinogenesis, it is appropriate to use proteins in a simple screening test for the detection of carcinogenesis. In this article, POC screening tests and the studies of discovery of CVF protein biomarkers will be overviewed to consider the development of a method that can be used for the rapid and conceivable screening method of CxCa.

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Bu Makaleye Atıf Yap

TAKMAZ, Ö., GÜNGÖR, M., BAYKAL, A. T., KÖSE, B. (2022). Point-of-care diagnosis of cervical cancer: potential protein biomarkers in cervicovaginal fluid. Turkish Journal of Biology, Cilt: 46 - Sayı: 3, 195–206. https://ajindex.com/articles/600088

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Kaynakça (7)

  1. Adnane M, Meade KG, O’Farrelly C (2018). Cervico-vaginal mucus (CVM)–an accessible source of immunologically informative biomolecules. Veterinary Research Communications 42 (4): 255-263.
  2. Appidi T, Mudigunda SV, Kodandapani S, Rengan AK (2020). Development of label-free gold nanoparticle based rapid colorimetric assay for clinical/point-of-care screening of cervical cancer. Nanoscale Advances 2 (12): 5737-5745.
  3. Arbyn M, Verdoodt F, Snijders PJ, Verhoef, Suonio VM et al. (2014). Accuracy of human papillomavirus testing on self-collected versus clinician-collected samples: a meta- analysis. Lancet Oncology 15 (2): 172–183.
  4. Arbyn M, Weiderpass E, Bruni L et al. (2020). Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. The Lancet Global Health 8 (2): e191-e203. Bal MD (2014). Evaluation of Women Having Pap Smear Test by Health Belief Model Scale. Clinical and Experimental Health Sciences 4 (3): 133-138.
  5. Bandu R, Oh JW, Kim KP (2020). Mass spectrometry-based proteome profiling of extracellular vesicles and their roles in cancer biology. Experimental & Molecular Medicine 51 (3): 1-10.
  6. Belokrinitskaya T, Frolova N, Turanova O, Pletneva V, Paltseva T et al. (2019). Efficiency and acceptability of human papillomavirus detection on self-collected versus clinician-collected samples in vaginal discharge. European Journal of Obstetrics and Gynecology and Reproductive Biology (234): e161. Boers A, Bosgraaf RP, Van Leeuwen RW, Schuuring E, Heideman DAM et al. (2014). DNA methylation analysis in self-sampled brush material as a triage test in hrHPV-positive women. British Journal of Cancer 111 (6): 1095. Borgdorff H, Gautam R, Armstrong SD, Xia D, Ndayisaba GF et al. (2016). Cervicovaginal microbiome dysbiosis is associated with proteome changes related to alterations of the cervicovaginal mucosal barrier. Mucosal Immunology 9 (3): 621. Boylan KL, Afiuni-Zadeh S, Geller MA, Hickey K, Griffin TJ et al. (2014). A feasibility study to identify proteins in the residual Pap test fluid of women with normal cytology by mass spectrometry-based proteomics. Clinical Proteomics 11 (1): 30. Calis P, Yuce K, Basaran D, Salman C (2016). Assessment of cervicovaginal cancer antigen 125 levels: a preliminary study for endometrial cancer screening. Gynecol Obstet Invest 81 (6): 518–522.
  7. Canfell K. (2019). Towards the global elimination of cervical cancer Papillomavirus Research 8: 100170. Casado-Vela J, Rodriguez-Suarez E, Iloro I, Ametzazurra A, Alkorta