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AI InsightProteinüri varl›¤› ve seviyesi, P/C oran›y- la olan iliflkisi ve bu bulgular ile perinatal sonuçlar aras›ndaki iliflki de¤erlendirildi.
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Özet
Amaç: Çal›flmam›zda, proteinürisi olan veya olmayan hipertansif gebelerde perinatal ve neonatal sonuçlar› de¤erlendirmeyi amaçla- d›k. Spot üriner protein ile kreatinin oran›n›n (P/C) ve 24-saatlik protein at›l›m›n›n sonuçlar üzerindeki prediktivitesini karfl›laflt›r- d›k. Yöntem: Gebeli¤in 20. ve 37. haftalar› aras›nda yeni hipertansiyon tan›s› alm›fl 230 gebe retrospektif olarak çal›flmaya dahil edildi. Al›- nan 24 saatlik idrar ve P/C ile belirlenen protein seviyesine göre hastalar iki gruba ayr›ld›. Proteinüri varl›¤› ve seviyesi, P/C oran›y- la olan iliflkisi ve bu bulgular ile perinatal sonuçlar aras›ndaki iliflki de¤erlendirildi. Bulgular: Do¤um esnas›ndaki gestasyonel yafl ve gecikme dönemi (hipertansiyon tan›s› ile do¤um aras›ndaki süre), ≥300 mg/24 saat ve P/C ≥0.3 de¤erlerine sahip gebelerde anlaml› flekilde daha er- kendi. Advers neonatal sonuçlar, proteinürisi ≥300 mg/24 saat ve P/C≥0.3 olan hastalarda anlaml›yd›. 24 saatlik idrarda üriner pro- tein seviyeleri, P/C ≥0.3 de¤erine sahip gebelerde anlaml› flekilde daha yüksekti ve 24 saatlik proteinüri ile P/C aras›nda anlaml› fle- kilde pozitif bir korelasyon bulundu (r=0.382, p
Abstract
Objective: Our study aimed to evaluate the perinatal and neonatal outcomes of hypertensive pregnant women with or without protein- uria. We compared the predictivity of spot urinary protein to crea- tinine (P/C) ratio and 24-hour protein excretions on outcomes. Methods: We retrospectively enrolled 230 pregnant women with a new diagnosis of hypertension between 20 and 37 weeks of gesta- tion. We divided the patients into two groups according to the pro- tein level determined by 24-hour urine collection and P/C ratio. The presence and level of proteinuria, its relationship with the P/C ratio, and the relationship between these findings and perinatal out- comes were evaluated. Results: Gestational age at delivery weeks and latency period (dura- tion between diagnosis of hypertension and delivery) were signifi- cantly earlier in pregnant women with ≥300 mg/24-h and P/C ratio ≥0.3. Adverse neonatal outcomes were significant in patients with proteinuria ≥300 mg/24-hour and P/C ratio ≥0.3. Urinary protein levels in 24-hour urine were significantly higher in pregnant women with P/C ratio ≥0.3 and a significantly positive correlation was found between 24-h proteinuria and P/C (r=0.382, p