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AI InsightBulgular: Yirmi normal yenido¤an aras›nda TNFα, IL1β ve IL6’n›n ortalama ± standart sapma de¤erleri s›ras›yla 39.7±21.5 pg/ml, 34.6± 20.9 pg/ml ve 44.4±33.0 pg/ml idi.
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Özet
Amaç: Neonatal sepsis tan›s› koymak için mevcut olan kabul görmüfl bir tan› testi bulunmamaktad›r. Bu bak›mdan tümör nekroz faktörü α (TNFα), interlökin 1 β (IL1β) ve interlökin 6 (IL6), yak›n tarihli baz› çal›flmalarda baz› umut verici sonuçlar sergilemifltir; fakat bun- lar›n neonatal sepsis tan›s› ve prognozundaki rolleri henüz kesinlefl- memifltir. Çal›flmam›zda, bu biyobelirteçlerin neonatal sepsisteki ta- n›lama ve prognostik kapasitelerini tespit etmeye çal›flt›k. Yöntem: Bu kesitsel çal›flmada, tan›lama kriterlerini karfl›layan 3 si- tokin için neonatal sepsis tan›s›nda amaçl› örnekleme ile kan örnek- leri al›nm›fl ve bulunan de¤erler normal sa¤l›kl› yenido¤anlar ile kar- fl›laflt›r›lm›flt›r. Her bir sitokin, en az %70 duyarl›l›k ve özgüllük ile neonatal sepsisi tespit edip edemeyeceklerini belirlemek için ayr› ay- r› de¤erlendirilmifltir. Ayn› esnada, hastal›k fliddeti ve mortalitesi ba- k›m›ndan prognostik de¤erleri de de¤erlendirilmifltir. Bulgular: Yirmi normal yenido¤an aras›nda TNFα, IL1β ve IL6’n›n ortalama ± standart sapma de¤erleri s›ras›yla 39.7±21.5 pg/ml, 34.6± 20.9 pg/ml ve 44.4±33.0 pg/ml idi. Sepsis grubunda (n=40) bu de¤er- ler s›ras›yla 69.6±26.0 pg/ml, 57.7±29.0 pg/ml ve 204.6±169.2) pg/ml bulundu. Tüm bu farkl›l›klar istatistiksel olarak anlaml›yd› (p
Abstract
Objective: There is no established diagnostic test available to diag- nose neonatal sepsis. Tumor necrosis factor α (TNFα), interleukin 1β (IL1β) and interleukin 6 (IL6) showed some promising results in some recent studies in this respect, but their roles in diagnosis and prognosis of neonatal sepsis are not yet conclusive. In this study, we have tried to identify diagnostic and prognostic ability of these bio- markers in neonatal sepsis. Methods: In this cross-sectional study, blood sample for 3 cytokines were collected at diagnosis of neonatal sepsis fulfilling diagnostic cri- teria by purposive sampling and values were compared with normal healthy newborns. Each of the cytokines was evaluated separately to identify, whether they can detect neonatal sepsis with at least 70% sensitivity and specificity. At the same time, their prognostic values were also evaluated in terms of disease severity and mortality. Results: Among twenty normal newborns, standard deviation values of TNFα, IL1β and IL6 were 39.7±21.5 pg/ml, 34.6±20.9 pg/ml and 44.4±33.0 pg/ml, respectively. In sepsis group (n=40), these values were 69.6±26.0 pg/ml, 57.7±29.0 pg/ml and 204.6±169.2 pg/ml, respectively. All these differences were statistically significant (p