Variant Histology: The Impact on Oncological Outcomes of Patients with Urothelial Carcinoma of The Bladder Treated with Radical Cystectomy

In the multivariable Cox regression analyses, the type of UC [hazard ratio (HR) 1.80, 95% confidence interval (CI) 1.00-3.24, p=0.050] and age (HR=1.050, 95% CI 1.016-1.086, p=0.004) was associated with the OS, whereas the LN metastases was associated the CSS (HR=2.962, 95% CI 1.456-6.027, p=0.003) and OS (HR=3.211, 95% CI 1.778-5.799, p

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: To investigate the impact of variant histology (VH) of urothelial carcinoma (UC) of the bladder on oncologic outcomes after radical cystectomy (RC).

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Temel Bulgular & Veri:Materials and Methods: We identified 125 patients with cT2-T4N0M0 UC who underwent RC without perioperative systemic therapy between 2014 and 2019 at a single tertiary care referral center.

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Sonuç & Katkı:In the multivariable Cox regression analyses, the type of UC [hazard ratio (HR) 1.80, 95% confidence interval (CI) 1.00-3.24, p=0.050] and age (HR=1.050, 95% CI 1.016-1.086, p=0.004) was associated with the OS, whereas the LN metastases was associated the CSS (HR=2.962, 95% CI 1.456-6.027, p=0.003) and OS (HR=3.211, 95% CI 1.778-5.799, p

🔬Tür:Araştırma Makalesi

📍Kapsam:2014 Verileri

⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: To investigate the impact of variant histology (VH) of urothelial carcinoma (UC) of the bladder on oncologic outcomes after radical cystectomy (RC). Materials and Methods: We identified 125 patients with cT2-T4N0M0 UC who underwent RC without perioperative systemic therapy between 2014 and 2019 at a single tertiary care referral center. The Mann-Whitney U test and chi-square test were used to compare the statistically significant differences in medians and proportions, respectively. The Kaplan-Meier method and Cox regression analyses tested the effect of different VH on cancer-specific survival (CSS) and overall survival (OS). Results: Of 125 patients, 70 (56%) had pure UC, whereas 55 (44%) had VH. The mean patient age and the median follow-up were 63.6±9.7 years and 12.5 (3-72) months. The female to male ratio was 13/112. The presence of lymphovascular invasion, locally advanced stage (≥pT3), and recurrence status were significantly higher in patients with VH than those with pure UC. In all patients, the presence of VH was not significantly associated with the presence of lymph node (LN) metastasis. In the multivariable Cox regression analyses, the type of UC [hazard ratio (HR) 1.80, 95% confidence interval (CI) 1.00-3.24, p=0.050] and age (HR=1.050, 95% CI 1.016-1.086, p=0.004) was associated with the OS, whereas the LN metastases was associated the CSS (HR=2.962, 95% CI 1.456-6.027, p=0.003) and OS (HR=3.211, 95% CI 1.778-5.799, p

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Bu Makaleye Atıf Yap

AKDOĞAN, B., BİLEN, C. Y., HABERAL, H. B., HAZIR, B., YAZICI, M. S., BALTACI, K. E., SHAHSUVARLI, P. (2022). Variant Histology: The Impact on Oncological Outcomes of Patients with Urothelial Carcinoma of The Bladder Treated with Radical Cystectomy. Journal of Urological Surgery, Cilt: 8 - Sayı: 4, 243–247. https://ajindex.com/articles/568613

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Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, Forman D, Bray F. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer 2013;49:1374- 1403
Rogers CG, Palapattu GS, Shariat SF, Karakiewicz PI, Bastian PJ, Lotan Y, Gupta A, Vazina A, Gilad A, Sagalowsky AI, Lerner SP, Schoenberg MP. Clinical outcomes following radical cystectomy for primary nontransitional cell carcinoma of the bladder compared to transitional cell carcinoma of the bladder. J Urol 2006;175:2048-2053
Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE. The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs- Part B: Prostate and Bladder Tumours. Eur Urol 2016;70:106-119
Moschini M, D’Andrea D, Korn S, Irmak Y, Soria F, Compérat E, Shariat SF. Characteristics and clinical significance of histological variants of bladder cancer. Nat Rev Urol 2017;14:651-668
Li Q, Assel M, Benfante NE, Pietzak EJ, Herr HW, Donat M, Cha EK, Donahue TF, Bochner BH, Dalbagni G. The Impact of Plasmacytoid Variant Histology on the Survival of Patients with Urothelial Carcinoma of Bladder after Radical Cystectomy. Eur Urol Focus 2019;5:104-108
Wang JK, Boorjian SA, Cheville JC, Kim SP, Tarrell RF, Thapa P, Frank I. Outcomes following radical cystectomy for micropapillary bladder cancer versus pure urothelial carcinoma: a matched cohort analysis. World J Urol 2012;30:801-806
Lin-Brande M, Pearce SM, Ashrafi AN, Nazemi A, Burg ML, Ghodoussipour S, Miranda G, Djaladat H, Schuckman A, Daneshmand S. Assessing the Impact of Time to Cystectomy for Variant Histology of Urothelial Bladder Cancer. Urology 2019;133:157-163
Koguchi D, Matsumoto K, Ikeda M, Taoka Y, Hirayama T, Murakami Y, Utsunomiya T, Matsuda D, Okuno N, Irie A, Iwamura M. Histologic variants associated with biological aggressiveness and poor prognosis in patients treated with radical cystectomy. Jpn J Clin Oncol 2019;49:373-378
Moschini M, Dell’Oglio P, Luciano’ R, Gandaglia G, Soria F, Mattei A, Klatte T, Damiano R, Shariat SF, Salonia A, Montorsi F, Briganti A, Colombo R, Gallina A. Incidence and effect of variant histology on oncological outcomes in patients with bladder cancer treated with radical cystectomy. Urol Oncol 2017;35:335-341
Shah RB, Montgomery JS, Montie JE, Kunju LP. Variant (divergent) histologic differentiation in urothelial carcinoma is under-recognized in community practice: impact of mand