This study shows that synthetic compound dihydrocapsaicin is widely use in dietary supplementsproducts for adulteration to increase the effects of product without any declaration.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:Adulteration of dietary supplements are serious threats to public health in all around of world.
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Temel Bulgular & Veri:A rapid LC-MS/MS method for determination of capsaicin and dihydrocapsaicinin dietary supplements via Fortis C18 (150 x 3 mm; 3 µm) column at 25 °C was developed and validated in amixture of mobile phase A (1 % formic acid solution and 0.1 % ammonium formate in water) and B (1 % formicacid solution and 0.1 % ammonium formate in methanol) with gradient program at a flow rate of 0.35 mL/min.
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Sonuç & Katkı:This study shows that synthetic compound dihydrocapsaicin is widely use in dietary supplementsproducts for adulteration to increase the effects of product without any declaration.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Abstract
Adulteration of dietary supplements are serious threats to public health in all around of world. Nowadays,in order to obtain the intended effect from natural remedies, the adulteration of natural products via artificial orharmful chemicals are increasing. A rapid LC-MS/MS method for determination of capsaicin and dihydrocapsaicinin dietary supplements via Fortis C18 (150 x 3 mm; 3 µm) column at 25 °C was developed and validated in amixture of mobile phase A (1 % formic acid solution and 0.1 % ammonium formate in water) and B (1 % formicacid solution and 0.1 % ammonium formate in methanol) with gradient program at a flow rate of 0.35 mL/min. Therecoveries of developed methods weytre obtained in the range of % 95.4-106.3 for capsaicin and % 96.3-108.9 fordihydrocapsaicin. This study shows that synthetic compound dihydrocapsaicin is widely use in dietary supplementsproducts for adulteration to increase the effects of product without any declaration.
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Bu Makaleye Atıf Yap
DİNÇEL, D., GÖREN, A. C., TIRIS, G., OLGAN, H., CANBALOĞLU, Z., YALÇIN, Ş., ERKÜÇÜK, A. (2022). Determination of dihydrocapsaicin adulteration in dietary supplements using LC-MS/MS. Journal of Chemical Metrology, Cilt: 14 - Sayı: 1, 77–82. https://ajindex.com/articles/560737
Y. Shim, J. Kim, and S. Jeong (2016). Simultaneous determination of piperine, capsaicin, and dihydrocapsaicin in Korean instant-noodle (Ramyun) soup base using high-performance liquid chromatography with ultraviolet detection, J. AOAC Int. 99(1), 187-92
Z. Othman, Y. Ahmed, M. Habila and A. Ghafar (2011). Determination of capsaicin and dihydrocapsaicin in Capsicum fruit samples using high performance liquid chromatography, Molecules 16 (10), 8919-8929
A. Durak, I. Kowalska and U. Gawlik-Dziki (2016). UPLC–MS method for determination of phenolic compounds in chili as a coffee supplement and their impact of phytochemicals interactions on antioxidant activity in vitro, Acta Chromatogr. 30 (1), 66-71
A. Alvarez, E. Maya and L. Suarez (2009). Analysis of capsaicin and dihydrocapsaicin in peppers and pepper sauces by solid phase microextraction-gas chromatography-mass spectrometry, J. Chromatogr. A, 1216 (14), 2843-2847
S. Varghese, P. Kubatka, L. Rodrigo, K. Gazdikova, M. Caprnda, J. Fedotova, A. Zulli, P. Kruzliak and D. Büsselberg (2017). Chili pepper as a body weight-loss food, Int. J. Food Sci. Nutr. 68 (4), 392-401
J. Zheng, S. Zheng, Q. Feng, Q. Zhang and X. Xiao (2017). Dietary capsaicin and its anti-obesity potency: from mechanism to clinical implications, Biosci. Rep, 37 (3), 1-9
S. Williams, R. Clark and J. Dunford (1995). Contact dermatitis associated with capsaicin: hunan hand syndrome, Ann Emerg. Med. 25 (5), 713-715
J. Burnett (1989). Capsicum pepper dermatitis. Cutis, 43 (6), 534-534
C. Reilly, J. Taylor, D. Lanza, B. Carr, D. Crouch and G. Yost (2003). Capsaicinoids Cause inflammation and epithelial cell death through activation of vanilloid receptors, Toxicol. Sci. 73 (1), 170-181
N. Kozukue, J. Han, E. Kozukue, S. Lee, J. Kim, K. Lee, C. Levin and M. Friedman (2005). Analysis of eight capsaicinoids in peppers and pepper-containing foods by high-performance liquid chromatography and liquid chromatography-mass spectrometry, J. Agric. Food Chem. 53 (23), 9172-9181
J. Rosas, J. Martinez, P. Alonso, R. Miranda, L. Velasco, L. Rubio-Perez and J. Perez (2019). Alternative mass spectrometry techniques for the validation of the fragmentation pattern of capsaicin and dihydrocapsaicin, Rapid Commun. Mass Spectrom. 33 (7), 635-640
A. Saria, F. Lembeck and G. Skofitsch (1981). Determination of capsaicin in tissues and separation of capsaicin analogues by high-performance liquid chromatography, J