Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightFurther multicentre randomised controlled trials about the use of biologic agents in these patient groups are necessary.
📌 3 Maddede Bu Makale
Abstract
Purpose: Patients with cutaneous inflammatory diseases often present with more aggressive and refractory clinical course in the presence ofaccompanying human immunodeficiency virus (HIV) infection. Therefore, biologic therapies may be needed to improve outcomes of thesepatients. The use of biologic agents in HIV positive patients is conflicting because such treatment can lead to increase the risk of infection andmalignancy in already immunocompromised patients. On the other hand, some researchers have recommended that HIV management shouldalso include the blockade of tumour necrosis factor-alpha (TNF-α). We discuss the reliability and effectiveness of biologic therapies for patientswith cutaneous inflammatory diseases and accompanying HIV infection.Methods: The Medline literature database search through PubMed using the key words ‘human immunodeficiency virus’, ‘cutaneousinflammatory diseases’, ‘TNF-α inhibitor’, ‘biologic therapy’, ‘biologic treatment’, ‘adalimumab’, ‘etanercept’, ‘infliximab,’ ‘ustekinumab’, and‘rituximab’ was performed. Literature data associated with biologic therapies of cutaneous inflammatory diseases in HIV-positive patients wereevaluated.Results: The literature search identified a total of 17 patients with HIV infection receiving biologic therapy for cutaneous inflammatory diseases(psoriasis, psoriatic arthritis, hidradenitis suppurativa and pemphigus vulgaris) from two case series and 12 case reports.Conclusion: In HIV-infected patients with severe and refractory cutaneous inflammatory diseases, biologic therapies should only be reservedfor those whom HIV status is stable at baseline. Screening for tuberculosis prior to treatment and close monitoring for potential side effects aremandatory. Further multicentre randomised controlled trials about the use of biologic agents in these patient groups are necessary.