Dergiler / Journal of Clinical and Analytical Medicine / 2015 / Cilt: 6 - Sayı: 5

Bastar Bölgesi'nde Staphylococcus aureus Klinik İzolatlarının Yaygınlığı ve İlaç Direnci

Prevalence and Drug Resistance Pattern of Staphylococcus aureus Clinical Isolates in Bastar Region

Sayfa
628–632
Yayın Tarihi
2022-10-18
DOI
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Cotrimoxazole and/or gentamycin may be considered as initial empiric treatment, but must be replaced immediately with the correct antibiotic according to the antibiogram.

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Amaç & Hipotez:Aim: The aim of this research was to study the prevalence and antibiotic resistance of S. aureus in the Bastar region.
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Temel Bulgular & Veri:Material and Method: From the clinical samples cultured from Jan 2010 to May 2012, 916 S. aureus isolates were identified by the standard tests.
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Sonuç & Katkı:Cotrimoxazole and/or gentamycin may be considered as initial empiric treatment, but must be replaced immediately with the correct antibiotic according to the antibiogram.
🔬Tür:Araştırma Makalesi
📍Kapsam:2010 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Aim: The aim of this research was to study the prevalence and antibiotic resistance of S. aureus in the Bastar region. Material and Method: From the clinical samples cultured from Jan 2010 to May 2012, 916 S. aureus isolates were identified by the standard tests. Screening of MRSA was done by oxacillin screen agar and cefoxitin disk diffusion tests. Antibiotic susceptibility was examined by Kirby-Bauer disk diffusion test. For MIC of vancomycin and linezolid, Etest was performed. Result: Of the isolates, 34.8% were MRSA. In the MRSA isolates, 63% (165) were found resistant to erythromycin, 39.3% (103) to azithromycin, 61.8% (162) to clindamycin, 81.5% (260) to cotrimoxazole, 0.6% (2) to linezolid, 0.9% (3) to vancomycin, 76.5% (244) to tetracycline, 67.7% (216) to gentamycin, 63.3% (202) to ciprofloxacin, 8.5% (27) to gatifloxacin, 16.4% (43) to chloramphenicol, 68.4% (39) to norfloxacin, 12.3% (7) to nitrofurantoin, 80.7% (46) to sulfisoxazole, and 80.7% (46) to trimethoprim antibiotics. Discussion: The study was conducted first time from this region. The prevalence and drug resistance percentage is compared with other studies. Emergence of linezolid resistance and relatively higher vancomycin resistance in the MRSA isolates is a worrisome finding of this study. Cotrimoxazole and/or gentamycin may be considered as initial empiric treatment, but must be replaced immediately with the correct antibiotic according to the antibiogram.

Abstract

Amaç: Bu araştırmanın amacı Bastar bölgedeki yaygınlığını ve S. aureus antibiyotik direncini etüd edilerek. Gereç ve Yöntem: Ocak 2010-Mayıs 2012 tarihinden itibaren, 916 S. aureus izolatı kültüre klinik örneklerden standart testlerle tespit edilmiştir. MRSA tespit oksasilin ekran ağar tarafından yapılan ve sefoksitin disk difüzyon testleri yapıldı. Kirby-Bauer disk difüzyon testi antibiyotik duyarlılık incelemek için kullanılmıştır. Vankomisin MIC ve linezolid Etest tarafından incelendi. Bulgular: Izolatların % 34.8 MRSA idi. MRSA izolatları içinde,% 63 (165) eritromisine dirençli bulunmuştur, azitromisine % 39.3 (103), klindamisin için % 61.8 (162), % 81.5 (260) kotrimoksazol için, % 0.6 (2) linezolide, % 0.9 (3) vankomisine, % 76.5 (244) tetrasiklin, % 67.7 (216) gentamisin için % 63.3 (202) siprofloksasin, % 8.5 (27) gatifloksasin için, % 16.4 (43), kloramfenikol % 68.4 (39 ) norfloksasin nitrofurantoine % 12.3 (7), Sulfısoxazol için % 80.7 (46) ve % 80.7 (46) antibiyotik trimetoprim için. Tartışma: Çalışması bu bölgeden ilk kez yapıldı. Prevalans ve ilaç direnci oranı diğer çalışmalar ile karşılaştırılmıştır. Linezolid direncinin ortaya çıkması ve MRSA izolatlarının görece yüksek vankomisin direnci bu çalışmanın endişe verici bir bulgudur. Kotrimoksazol ve/veya gentamisin ilk ampirik tedavisi olarak kabul edilebilir, ancak Antibiyograma göre doğru bir antibiyotik ile hemen değiştirilmelidir.

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Bu Makaleye Atıf Yap

KHAN, M. F., KHAN, F. A., PATİL, S. (2022). Bastar Bölgesi'nde Staphylococcus aureus Klinik İzolatlarının Yaygınlığı ve İlaç Direnci. Journal of Clinical and Analytical Medicine, Cilt: 6 - Sayı: 5, 628–632. https://ajindex.com/articles/551909

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