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Dergiler / İstanbul Kuzey Klinikleri / 2020 / Cilt: 7 - Sayı: 1

Tumor suppressor and oncogenic role of long non-coding RNAs in cancer

Burhanettin YALÇINKAYA
Esra GÜZEL
Tuğba Muhlise OKYAY
Şeymanur KARACAOĞLU
Melek GÖÇMEN
Muhammed Hüseyin AKÇAKUYU
Sayfa
81–86
Yayın Tarihi
2022-10-18
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In this review, general information about lncRNAs is provided, includingthe biological importance of lncRNAs in cancer diseases and their potential development in therapeutic applications.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Non-coding RNAs are RNA molecules that are not translated into the protein, making up the vast majority of the humangenome.
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Temel Bulgular & Veri:Long non-coding RNAs (lncRNA) are in the RNA group that has longer than 200 nucleotides, and non-protein coding transcripts.
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Sonuç & Katkı:In this review, general information about lncRNAs is provided, includingthe biological importance of lncRNAs in cancer diseases and their potential development in therapeutic applications.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Non-coding RNAs are RNA molecules that are not translated into the protein, making up the vast majority of the humangenome. Long non-coding RNAs (lncRNA) are in the RNA group that has longer than 200 nucleotides, and non-protein coding transcripts. In recent years, the potential has attracted considerable attention as new important biological regulators.LncRNAs play a critical role in regulating the activity and localization of proteins, processing the production of small RNAs, andprocessing other RNAs. They are also involved in cell differentiation, cell cycle, proliferation, apoptosis, migration and invasion by modulation of gene expression. Abnormal expression of LncRNAs has an important role in the function of oncogenesand tumor suppressor genes. Recently, there has been an increasing number of studies on the tumorigenic effects of specificlncRNAs in the initiation and progression of cancer. In this review, general information about lncRNAs is provided, includingthe biological importance of lncRNAs in cancer diseases and their potential development in therapeutic applications.

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Bu Makaleye Atıf Yap

YALÇINKAYA, B., GÜZEL, E., OKYAY, T. M., KARACAOĞLU, Ş., GÖÇMEN, M., AKÇAKUYU, M. H. (2022). Tumor suppressor and oncogenic role of long non-coding RNAs in cancer. İstanbul Kuzey Klinikleri, Cilt: 7 - Sayı: 1, 81–86. https://ajindex.com/articles/551442

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