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Dergiler / International Journal of Secondary Metabolite / 2020 / Cilt: 7 - Sayı: 2

Investigation of Some Corticosteroids as Glutathione Reductase Inhibitor

Esra ŞENTÜRK
Murat ŞENTÜRK
Sayfa
119–125
Yayın Tarihi
2022-10-19
DOI
—
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These corticosteroids exhibit very potent inhibitory activity against GR enzyme at low micromolar concentrations when compared to well-known GRIs.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The detection of glutathione reductase inhibitors (GRIs) has recently become very popular due to their use as malarial and cancer drugs.
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Temel Bulgular & Veri:IC50 values were determined by drawing % activity-[I] graphs for these corticosteroids showing inhibition effects.
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Sonuç & Katkı:These corticosteroids exhibit very potent inhibitory activity against GR enzyme at low micromolar concentrations when compared to well-known GRIs.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Steroid · Glutathione reductase · Inhibition

Özet

The detection of glutathione reductase inhibitors (GRIs) has recently become very popular due to their use as malarial and cancer drugs. Today, steroidal compounds have several clinical roles due to their potent immunomodulating and anti-inflammatory properties. In this study, GR inhibitory capacity of some corticosteroids (dexamethasone, prednisolone and methylprednisolone) has been reported. Amongst these steroidal molecules dexamethasone showed the weakest inhibitory effect on GR enzyme. IC50 values were determined by drawing % activity-[I] graphs for these corticosteroids showing inhibition effects. These corticosteroids have inhibition ranging micromolar for GR with IC50 values. These corticosteroids exhibit very potent inhibitory activity against GR enzyme at low micromolar concentrations when compared to well-known GRIs.

Abstract

The detection of glutathione reductase inhibitors (GRIs) has recently become very popular due to their use as malarial and cancer drugs. Today, steroidal compounds have several clinical roles due to their potent immunomodulating and anti-inflammatory properties. In this study, GR inhibitory capacity of some corticosteroids (dexamethasone, prednisolone and methylprednisolone) has been reported. Amongst these steroidal molecules dexamethasone showed the weakest inhibitory effect on GR enzyme. IC50 values were determined by drawing % activity-[I] graphs for these corticosteroids showing inhibition effects. These corticosteroids have inhibition ranging micromolar for GR with IC50 values. These corticosteroids exhibit very potent inhibitory activity against GR enzyme at low micromolar concentrations when compared to well-known GRIs.

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Bu Makaleye Atıf Yap

ŞENTÜRK, E., ŞENTÜRK, M. (2022). Investigation of Some Corticosteroids as Glutathione Reductase Inhibitor. International Journal of Secondary Metabolite, Cilt: 7 - Sayı: 2, 119–125. https://ajindex.com/articles/541648

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Kaynakça (8)

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