Dergiler / International Advanced Researches and Engineering Journal / 2019 / Cilt: 3 - Sayı: 1

Determination of highly effective attributes in fold level classification of proteins

Sayfa
32–39
Yayın Tarihi
2022-10-19
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In this study, a classic classifier KNN (K-nearest neighbor) and artificial neural network models GAL (Grow and Learn) and SOM (Self-Organizing Map) networks are used as classifier and classification performance is analyzed for reduced dimension datasets.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:In this paper it is aimed to determine which of the protein features or attributes is the most significant for classification of proteins according to their folds.
📊
Temel Bulgular & Veri:Proteins in the database used in this study are represented by six feature groups called attributes and by a 125-dimensional feature vector.
💡
Sonuç & Katkı:In this study, a classic classifier KNN (K-nearest neighbor) and artificial neural network models GAL (Grow and Learn) and SOM (Self-Organizing Map) networks are used as classifier and classification performance is analyzed for reduced dimension datasets.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:divergence analysis · fold recognition attrbutes · neural networks

Abstract

In this paper it is aimed to determine which of the protein features or attributes is the most significant for classification of proteins according to their folds. Proteins in the database used in this study are represented by six feature groups called attributes and by a 125-dimensional feature vector. The representation of proteins with very high dimensional vectors such as 125 causes increasing computational load of the classification process and extending the process time. In this study “dimension reduction” solution is offered for this negative situation. Hence, with two different approaches, the features and attributes having high classification performance are determined. In the first approach, which attribute gives higher performance is determined by testing separately each of the six attributes. In the second approach, the most significant of the 125 features are determined using Divergence Analysis method. In this study, a classic classifier KNN (K-nearest neighbor) and artificial neural network models GAL (Grow and Learn) and SOM (Self-Organizing Map) networks are used as classifier and classification performance is analyzed for reduced dimension datasets.

🔖

Bu Makaleye Atıf Yap

POLAT, Ö. (2022). Determination of highly effective attributes in fold level classification of proteins. International Advanced Researches and Engineering Journal, Cilt: 3 - Sayı: 1, 32–39. https://ajindex.com/articles/539361

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Hashemi, H.B., Shakery, A., Naeini, M.P, Protein fold pattern recognition using Bayesian ensemble of RBF neural networks, in SOCPAR2009: Malaysia. p. 436-441
  2. Cantoni, V., Ferone, A., Ozbudak, O. and Petrosino, A., Searching structural blocks by SS exhaustive matching, Lecture Notes in Bioinformatics. Leif Peterson, Giuseppe Russo, Francesco Masulli (Eds.), 2013. p. 57-69
  3. Protein Data Bank, http://www.rcsb.org, last access date: 31.12.2018
  4. Murzin, A.G., Brenner, S.E., Hubbard, T. and Chothia, C., SCOP: A structural classification of proteins database for the investigation of sequences and structures, Journal of Molecular Biology, 1995. 247(4), p. 536–540
  5. Dubchak, I., Muchnik, I., Mayor, C., Dralyuk, I. and Kim, S.H., Recognition of a protein fold in the context of the structural classifications of proteins (SCOP) classification, Proteins: Structure, Function and Bioinformatics, 1999. 35(4), p. 401–407
  6. Reczko, M. and Bohr, H., The DEF data base of sequence based protein fold class predictions, Nucleic acids research, 1994. 22(17), p. 3616-3619
  7. Edler, L., Grassmann, J. and Suhai, S., Role and results of statistical methods in protein fold class prediction, Mathematical and Computer Modelling, 2001. 33(12), p. 1401–1417
  8. Ding, C.H.Q. and Dubchak, I., Multi-class protein fold recognition problem using support vector machines and neural networks, Bioinformatics, 2001. 17(4), p. 349–358
  9. Bologna, G. and Appel, R.D., A comparison study on protein fold recognition, Proceedings of the 9th International Conference on Neural Information Processing, 2002. volume 5, IEEE, p. 2492–2496
  10. Igel, C., Gebert, J. and Wiebringhaus, T., Protein fold class prediction using neural networks with tailored early-stopping,, Proceedings of IEEE International Joint Conference on Neural Networks,2004. volume 3, p. 1693–1697
  11. Huang, C.D., Liang, S.F., Lin, C.T. and Wu, R.C., Machine learning with automatic feature selection for multi-class protein fold classification, Journal of information science and engineering, 2005. 21(4), p. 711–720
  12. Jazebi, S., Tohidi, A. and Rahgozar, M., Application of classifier fusion for protein fold recognition, Sixth International Conference on Fuzzy Systems and Knowledge Discovery, 2009. volume 7, p.171–175
  13. Chinnasamy, A., Sung, W.K. and Mittal, A., Protein structure and fold prediction using tree-augmented naive Bayesian classifier, Journal of Bioinformatics and Computational Biology, 2005. 3(04), p. 803–8