Dergiler / Haydarpaşa Numune Medical Journal / 2021 / Cilt: 61 - Sayı: 2

The Relation Between Neutrophil-Lymphocyte Ratio and Etiologic Subtypes in Acute Ischaemic Stroke

Sayfa
145–148
Yayın Tarihi
2022-10-19
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

We think that more detailed investigation for cardioembolic sources may be necessary in patients with high NLR at first admission.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Introduction: The role of leukocytes in tissue damage in acute ischaemic stroke is well-known.
📊
Temel Bulgular & Veri:Methods: In this study, acute ischaemic stroke patients who were admitted to our hospital in the first 24 hours were in- cluded.
💡
Sonuç & Katkı:We think that more detailed investigation for cardioembolic sources may be necessary in patients with high NLR at first admission.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Introduction: The role of leukocytes in tissue damage in acute ischaemic stroke is well-known. There are some studies exam- ining the relationship between etiologic subtypes of acute ischaemic stroke and neutrophil/lymphocyte ratio (NLR). In this study, we planned to investigate the relationship between NLR and etiologic subtypes of acute ischaemic stroke. Methods: In this study, acute ischaemic stroke patients who were admitted to our hospital in the first 24 hours were in- cluded. Etiologic classification of patients was done by TOAST classification system. Patients who had history of acute coro- nary syndrome and pulmonary emboli were excluded. Results: We included 467 acute ischemic stroke patients and 162 control patients. Of the patients, 239 were females (51%) and 228 were males (49%). Of the control group, 77 (47%) were females and 85 (53%) were males. Mean ages in patient and control groups were 69.41±14.4 and 67.35±19.41, respectively. NLR’s in acute stroke and control groups were 3.38±3.43 and 2.12±1.11, respectively, and this difference was found to be statistically significant (p=0.001). NLR’S in atherothrombotic and cardioembolic groups were 3.26±2.35 and 4.46±5.6, respectively, and this was found to be statistically significant (p=0.03). Discussion and Conclusion: High NLR was found to be related with cardioembolic etiology in acute ischaemic stroke. We think that more detailed investigation for cardioembolic sources may be necessary in patients with high NLR at first admission.

🔖

Bu Makaleye Atıf Yap

KARACI, R., DOMAÇ, F., ÜLKER, M., DEMİR, M. (2022). The Relation Between Neutrophil-Lymphocyte Ratio and Etiologic Subtypes in Acute Ischaemic Stroke. Haydarpaşa Numune Medical Journal, Cilt: 61 - Sayı: 2, 145–148. https://ajindex.com/articles/535917

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Dalal PM, Malik S, Bhattacharjee M, Trivedi ND, Vairale J, Bhat P, et al. Population-based stroke survey in Mumbai, In- dia: Incidence and 28-day case fatality. Neuroepidemiology 2008;31:254–61
  2. Suh B, Shin DW, Kwon HM, Yun JM, Yang HK, Ahn E, et al. Ele- vated neutrophil to lymphocyte ratio and ischemic stroke risk in generally healthy adults. PLoS One 2017;12:e0183706
  3. Emerging Risk Factors Collaboration, Kaptoge S, Di Angelan- tonio E, Pennells L, Wood AM, White IR, Gao P, et al. Creactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med 2012;367:1310–20
  4. Fu Y, Liu Q, Anrather J, Shi FD. Immune interventions in stroke. Nat Rev Neurol 2015;11:524–35
  5. Kim JY, Park J, Chang JY, Kim SH, Lee JE. Inflammation after is- chemic stroke: The role of leukocytes and glial cells. Exp Neu- robiol 2016;25:241–51
  6. Barone FC, Hillegass LM, Price WJ, White RF, Lee EV, Feuerstein GZ, et al. Polymorphonuclear leukocyte infiltration into cere- bral focal ischemic tissue: Myeloperoxidase activity assay and histologic verification. J Neurosci Res 1991;29:336–45
  7. Herz J, Sabellek P, Lane TE, Gunzer M, Hermann DM, Doepp- ner TR. Role of neutrophils in exacerbation of brain injury after focal cerebral ischemia in hyperlipidemic mice. Stroke 2015;46:2916–25
  8. Matsuo Y, Kihara T, Ikeda M, Ninomiya M, Onodera H, Kogure K. Role of neutrophils in radical production during ischemia and reperfusion of the rat brain: Effect of neutrophil deple - tion on extracellular ascorbyl radical formation. J Cereb Blood Flow Metab 1995;15:941–7
  9. Kim J, Song TJ, Park JH, Lee HS, Nam CM, Nam HS, et al. Differ- ent prognostic value of white blood cell subtypes in patients with acute cerebral infarction. Atherosclerosis 2012;222:464–7
  10. Grøgaard B, Schürer L, Gerdin B, Arfors KE. Delayed hypoper- fusion after incomplete forebrain ischemia in the rat. The role of polymorphonuclear leukocytes. J Cereb Blood Flow Metab 1989;9:500–5
  11. Easton AS. Neutrophils and stroke-can neutrophils mitigate disease in the central nervous system? Int Immunopharmacol 2013;17:1218–25
  12. Krams M, Lees KR, Hacke W, Grieve AP, Orgogozo JM, Ford GA, ASTIN Study Investigators. Acute stroke therapy by inhibition of neutrophils (ASTIN): An adaptive dose-response study of UK-279,276 in acute ischemic stroke. Stroke 2003;34:2543–8
  13. Enlimomab Acute Stroke Trial Investigators. Use of an- ti-ICAM-1 therapy in ischemic stroke: Results of the enlimom- ab acute stroke trial. Ne