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Dergiler / Hacettepe Journal of Biology and Chemistry / 2009 / Cilt: 37 - Sayı: 4

Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen

Fatma AYHAN
Mine ÖZYAZICI
Nazlı SÖKMEN
Seda UYSAL
Hakan AYHAN
Sayfa
337–343
Yayın Tarihi
2022-10-17
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The release mechanism was found to obey Higuchi and first order kinetics when the release data of the formulations were applied to the models in the different pH mediums.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In this study, poly(ethylene glycol-diacrylate) (PEG-DA) hydrogels with two different concentrations, 30% and 50% w/w, were prepared by free radical polymerization method.
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Temel Bulgular & Veri:Ethylene glycol dimethacrylate (EGDMA) and 2,2-dimethoxy-2-phenyl-acetophenone (DMPA) were used as cross-linking agent and photoinitiator, respectively.
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Sonuç & Katkı:The release mechanism was found to obey Higuchi and first order kinetics when the release data of the formulations were applied to the models in the different pH mediums.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

In this study, poly(ethylene glycol-diacrylate) (PEG-DA) hydrogels with two different concentrations, 30% and 50% w/w, were prepared by free radical polymerization method. Ethylene glycol dimethacrylate (EGDMA) and 2,2-dimethoxy-2-phenyl-acetophenone (DMPA) were used as cross-linking agent and photoinitiator, respectively. The model drug ketoprofen (KP) was incorporated into the hydrogel during photopolymerization and its release kinetics was tested spectrophotometrically at 256 nm in different buffer solutions of pH 7.5, 4.5, and 1.2. The results showed that the release of KP strongly depends on the dissolution of drug, initial polymer concentration, and the pH of the release medium. All of the obtained results were evaluated kinetically by first order and zero order, Higuchi and Hixon-Crowell kinetic models. The release mechanism was found to obey Higuchi and first order kinetics when the release data of the formulations were applied to the models in the different pH mediums.

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Bu Makaleye Atıf Yap

AYHAN, F., ÖZYAZICI, M., SÖKMEN, N., UYSAL, S., AYHAN, H. (2022). Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen. Hacettepe Journal of Biology and Chemistry, Cilt: 37 - Sayı: 4, 337–343. https://ajindex.com/articles/529305

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Kaynakça (15)

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