No trace of acetylated pyrrolidine was observed where acylated morpholine was isolated Key Words in good yields when morpholine enamines were reacted.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:Acylation reaction of a variety of cyclic ketones via acylation of the corresponding enamines is well-defined in the literature.
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Temel Bulgular & Veri:Enamine acylation of carbonyl compounds is a significant synthetic method because of its mildness and the ease of preparing various β- diketones.The pyrrolidine and morpholine enamines of cyclic ketones such as cyclohexanone and cyclopentanone were successfully reacted with phenylacetyl chloride and chloroacetyl chloride respectively, to yield various acetylated or diacetylated enamines.
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Sonuç & Katkı:No trace of acetylated pyrrolidine was observed where acylated morpholine was isolated Key Words in good yields when morpholine enamines were reacted.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Abstract
Acylation reaction of a variety of cyclic ketones via acylation of the corresponding enamines is well-defined in the literature. Enamine acylation of carbonyl compounds is a significant synthetic method because of its mildness and the ease of preparing various β- diketones.The pyrrolidine and morpholine enamines of cyclic ketones such as cyclohexanone and cyclopentanone were successfully reacted with phenylacetyl chloride and chloroacetyl chloride respectively, to yield various acetylated or diacetylated enamines. No trace of acetylated pyrrolidine was observed where acylated morpholine was isolated Key Words in good yields when morpholine enamines were reacted.
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Bu Makaleye Atıf Yap
ŞENÖZ, H., TUNOĞLU, N. (2022). Acetylation of some cyclic enamines with substituted acetyl chlorides. Hacettepe Journal of Biology and Chemistry, Cilt: 38 - Sayı: 2, 95–106. https://ajindex.com/articles/529281
Stork, G., Terrel, R., Szmuszkovicz, J., A new synthesis of 2-alkyl and 2-acyl ketones [4], J. Am. Chem. Soc., 76, 2029, 1954
Stork, G., Brizzolara, A., Landesman, H., A new alkylation of carbonyl compounds. II [5], J. Am. Chem. Soc., 78, 5128, 1956
Stork, G., Brizzolara, A., Landesman, H., Szmuszkovicz, J., Terrel, R., The enamine alkylation and acylation of carbonyl compounds, J. Am. Chem. Soc. 85, 207, 1963
Verboom, W., Reinhoudt, D.N., Harkema, S., Van Hummel, G.J., Reactions of enamines with trifluoroacetic anhydride: Trifluoroacetylation and the formation of 1,3- oxazines, J. Org. Chem. 47, 3339, 1982
Özbey, S, Kaynak, F.B, Şenöz, H., Tunoğlu, N., Crystal structures of N-(trichloroacetyl)morpholine and 2,6- di(trichloroacetyl)cyclohexanone, Z. Kristallogr. 218, 440, 2003
Krepski, L.R., Hassner, A., An improved procedure for the addition of dichloroketene to unreactive olefins, J.Org. Chem. 43, 2879, 1978
Hunig, S., Benzing, E., Lücke, E., Synthesen mit enaminen.1. Acylierung mit carbonsaurechloriden, Chem. Ber.-Recue., 90, 2833, 1957.