Molecularly imprinted polymer for serotonin recognition

Temel Bulgular & Veri:Serotonin (5-hydroxytryptamine) is a biogenic amine that acts as a neurotransmitter in the central and peripheral nervous systems.

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Sonuç & Katkı:The specifity of polymer was tested by real blood sample.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Abstract

Developing of new techniques for detecting important biologic molecules are one of the aims of molecular imprinting. Serotonin (5-hydroxytryptamine) is a biogenic amine that acts as a neurotransmitter in the central and peripheral nervous systems. It is present in a variety of organisms, ranging from humans to species such as worms that have primitive nervous systems, and mediates a variety of physiological responses in distinct cell types. Serotonin is one of the indolic compound which has a clinical importance. Serotonin imprinted polymers were synthesized by using different functional monomers. Best results were taken with 2-(trifluoromethyl) acrylic acid and methacrylamide. The binding capacities in different solvents were evaluated. The specifity of polymer was tested by real blood sample.

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Bu Makaleye Atıf Yap

TELEFONCU, A., OKUTUCU, B., HAUPT, K. (2022). Molecularly imprinted polymer for serotonin recognition. Hacettepe Journal of Biology and Chemistry, Cilt: 38 - Sayı: 2, 79–84. https://ajindex.com/articles/529272

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Kaynakça (14)

Jacobs, B.I., Azmitia, C.E. Structure and function of brain serotonin system, Physiol. Rev. 72, 165, 1992
Hen R. Of mice and flies: Commonalities among 5-HT receptors. Trends Pharmacol. Sci.13,160, 1992
Wilkinson, L.O., Dourish, C.T. Serotonin and animal behavior. In: Peroutka, S.J., Editor, Serotonin Receptor Subtypes: Basic and Clinical Aspects, Wiley, New York, 147–210, 1991
Cases, O., Seif, I., Grimsby, J., Gaspar, P., Chen, K., Pournin, S., Müler, U., Aguet, M., Babinet, C., Shih, J.C., Maeyer, E. Aggressive behaviour and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA, Science, 268, 1763, 1995
Yeh, S.R., Fricke, R.A., Edwards, D.H. The effect of social experience on serotonergic modulation of the escape circuit of crayfish. Science. 271, 366, 1996
Lopez-Ibor JJ Jr. The involvement of serotonin in psychiatric disorders and behaviour. Br J Psychiatry, 153, 26, 1988
Tecott, L,H., Sun, L.M., Akana, S.F., Strack, A.M., Lowenstein, D.H., Dallman, M.F. Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors. Nature 374, 542, 1995
Kema, I,P., Vries, E.G.E., Muskiet, F.A.J. Clinical Chemistry Of Serotonin And Metabolites, J. Chromatogr. B: Biomed Sci Appl. 747, 33, 2000
Welch, K.M.A., Meyer, J.S., Kwant, S. Estimation of levels of serotonin and 5-hydroxyindoles in whole blood by an autoanalytical procedure: observations on the blood-brain barrier. J. Neurochem. 19, 1079, 1972
Anderson, G.M., Young, J.G. Applications of liquid chromatographic-fluorometric systems in neurochemistry. Life Sci. 28, 507, 1981
Patel, B.A., Arundell, M., Parker K.H., Yeoman, M.S., O’Hare, D. Simple and rapid determination of serotonin and catecholamines in biological tissue using high-performance liquid chromatography with electrochemical detection. J. Chromatogr. B.818, 269, 2005
Sasaki, T., Fukushima, T., Ohishi, M., Toyo’oka, T. Development of a 6-hydroxychroman-based derivatization reagent: application to the analysis of 5-hydroxytryptamine and catecholamines by using high-performance liquid chromatography with electrochemical detection. Biomed. Chromatogr. 22, 888, 2008
Parrot, S., Lambes-Senas, L., Sentenac, S., Denoray, L., Renaud, J. Highly sensitive assay for the measurement of serotonin in microdialysates using capillary highperformance liquid chromatography with electrochemical detection. Chromatogr. B.850, 303, 2007
Yoshitake, T., Fujino, K., Kehr, J., Ishida, J., Yam