Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightMore comprehensive and comparative studies should be conducted on this subject.
📌 3 Maddede Bu Makale
Abstract
Purpose: The role of endoplasmic reticulum stress has not yet been investigated in corneal inflammation. In this preliminary study, we aimed to find out whether endoplasmic reticulum stress inhibition has an effect on inflammation and neovascularization after alkaline burn and to find the effective dose. Materials and Methods: Salubrinal was used as an endoplasmic reticulum stress inhibitor. The study was carried out on Wistar rats of 250- 300 mg divided into four groups, with 1 animal in each group. After the corneal neovascularization (CNV) model was created in the right eyes, subconjunctival salubrinal was administered at doses of 0.1; 0.25; 0.5 and 1 mg/kg respectively. Subconjunctival Salubrinal was applied to the left eyes without creating a CNV model. Histopathological results were evaluated in the corneal tissues taken from animals that were sacrificed on the 14th day. Results: As a result of histopathological evaluation performed in 4 groups, inflammation and vascularization were observed in the groups given 0.1 mg / kg, 0.25 mg / kg and 0.5 mg / kg salubrinal, respectively. In the group given 1 mg / kg salurinal, it was observed that inflammation was less than the other groups and there was no vascular structures. In any group, salubrinal did not show toxic effects on intact corneal tissue histologically. Discussion: Inhibition of endoplasmic reticulum stress, which is a pathway of inflammation, can be used in the treatment of inflammation and corneal neovascularization caused by alkaline burns. More comprehensive and comparative studies should be conducted on this subject.