Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightHowever, further studies of this variant with larger samplesizes and different ethnicities are required for confirmation.
📌 3 Maddede Bu Makale
Abstract
Objective: Behçet’s disease (BD), a chronic multisystem inflammatory disorder, is mainly characterizedby relapsing periods of a wide range of clinical symptoms. Several cytokine genes may play importantroles in the pathogenesis of BD. Therefore, interleukin-1 receptor antagonist (IL-1Ra) gene 86bp variablenumber tandem repeat (VNTR) variant was investigated in patients with BD in a Turkish population.Methods: One hundred nine patients (60 females, 49 males; the mean age±standard deviation [SD]was 36.56±9.571 years) with BD and one hundred healthy individuals (54 females, 46 males; the meanage±SD was 36.64±2.294 years) were examined in the study. For genotyping, polymerase chain re-action-restriction fragment length polymorphism analysis was employed. Data were analyzed usingStatistical Package for Social Sciences (SPSS) 22.0 (IBM Corp.; Armonk, NY, USA) (p0.05). The frequency of the a1/a1, a1/a2 geno-types and a1, a2 alleles were the most common both in patients and healthy controls (p=0.37, p=0.26,and p=0.53, respectively). Also, no statistically significant difference was found between the IL-1RaVNTR variant genotypes and clinical characteristics (p>0.05).Conclusion: The results of this study do not support an association between the IL-1Ra VNTR variantand the risk of BD in a Turkish population. However, further studies of this variant with larger samplesizes and different ethnicities are required for confirmation.