Free radical content of drugs used in ophthalmology

Temel Bulgular & Veri:İntrakameral ve intravitreal kullanılan 25 ilaç örneği, fortifiye damla olarak kullanılan 11 ilaç örneği, uzun süreli kullanılan 30 göz damlası örneği ve farklı yaş ve cins hastadan alınan 8 otolog serum örneği serbest radikal varlığını analiz etmek için total oksidan status kiti kullanıldı.

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Sonuç & Katkı:Cerrah hastalıklı göz varlığında oksi- datif doku hasarı riskini göz önünde bulundurmalıdır.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Özet

Oftalmolojide kullanılan ilaçlarda bulunan serbest radikallerin varlığını incelemek. İntrakameral ve intravitreal kullanılan 25 ilaç örneği, fortifiye damla olarak kullanılan 11 ilaç örneği, uzun süreli kullanılan 30 göz damlası örneği ve farklı yaş ve cins hastadan alınan 8 otolog serum örneği serbest radikal varlığını analiz etmek için total oksidan status kiti kullanıldı. En yüksek serbest radikal konsantrasyonu intrakameral grupta moksifloxacinde (Vigamox), intravitreal grupta klindamisinde, antiglokom grubunda brinzolamidde ölçüldü. Oftalmolojide kullanılan ilaçlarda serbest radikaller bulunmaktadır. Cerrah hastalıklı göz varlığında oksi- datif doku hasarı riskini göz önünde bulundurmalıdır.

Abstract

To evaluate the presence of free radicals in various drugs used in ophthalmology. Twenty five samples of drugs that are used by intracameral or intravitreal route, eleven samples of drugs used as fortified eye drop, thirty samples of topical commercial preparations that are used as long term, and eight samples of autologous serum were analyzed for total free radical presence using a kit for total oxidant status. The highest free radical concentration was in Moxifloxacin (Vigamox) in intracameral group, clindamycin in intravitreal group, brinzolamide in antiglaucoma group. Free radicals are present in drugs used in ophthalmology. The surgeon should consider the risk of oxidative damage in the presence of diseased eye.

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Bu Makaleye Atıf Yap

OZCİMEN, M., SAKARYA, Y., SAKARYA, R., KARA, S., KURKU, H. (2022). Free radical content of drugs used in ophthalmology. European Journal of General Medicine, Cilt: 9 - Sayı: 2, 85–90. https://ajindex.com/articles/511080

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