Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightBecause of the high rate of hormone receptor positivity, hormonal therapy is the mainstay for the treatmentof estrogen receptor (ER)+ male breast cancer.
📌 3 Maddede Bu Makale
Abstract
Objective: Male breast cancer (MBC) is a rare type of cancer in the breast cancer series and in the male population. Data is usually extrapolatedfrom female breast cancer (FBC) studies. We aim to study the clinicopathological characteristics and outcome of MBC patients at our institutionand we aim to emphasize the differences compared with FBC.Materials and Methods: Between January 1993 and April 2016, 56 male patients who were diagnosed as breast cancer and underwent surgicaloperation were retrospectively analyzed. Patients were evaluated for demographical characteristics, surgery type, clinicopathological characteristics,adjuvant and neoadjuvant treatments, follow-up time, overall survival (OS), disease free survival (DFS), and disease specific survival (DSS).Results: The ratio of MBC among all breast cancers at our institution is 1%. The median age was 64 (34-85). Surgical procedures were modifiedradical mastectomy (MRM) in 41 patients (77%), simple mastectomy in 11 patients (21%), and lumpectomy in 1 patient (2%). Two patients wereStage 0 (4%), 7 were Stage 1 (13%), 12 were Stage 2 (22.6%), and 32 were Stage 3 (60.4%). Molecular subtypes of the invasive tumors were luminalA in 40 (80%), luminal B in 6 (12%), HER-2 type in 1 (2%), and basal-like in 3 (6%). Median follow-up time was 77 (3-287) months. 5-year and10-year OS, DFS, and DSS rates were 80.7%, 96%, 95.6% and 71.6%, 81.9%, 91.7% respectively.Conclusion: MBC presents different clinicopathological and prognostic factors when compared to FBC. Our survival rates are higher than theaverage presented in available literature. Because of the high rate of hormone receptor positivity, hormonal therapy is the mainstay for the treatmentof estrogen receptor (ER)+ male breast cancer.