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Dergiler / Eurasian Journal of Medicine and Oncology / 2021 / Cilt: 5 - Sayı: 4

Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas

Mahmut Buyuksimsek
Semra Paydas
Emine Kilic Bagir
Melek Ergin
Gulsah Seydaoglu
Sayfa
327–331
Yayın Tarihi
2022-10-12
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

We found that DUSP22 is poor prognostic indicator in cases with low grade lymphomas.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objectives: Dual specificity phosphatase 22 (DUSP22) is a novel phosphatase and has been demonstrated to be a cancer suppressor gene associated with various biological and pathological processes.
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Temel Bulgular & Veri:The aim of this study is to evaluate the prognostic importance of DUSP22 expression in low-grade lymphomas.
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Sonuç & Katkı:We found that DUSP22 is poor prognostic indicator in cases with low grade lymphomas.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objectives: Dual specificity phosphatase 22 (DUSP22) is a novel phosphatase and has been demonstrated to be a cancer suppressor gene associated with various biological and pathological processes. The aim of this study is to evaluate the prognostic importance of DUSP22 expression in low-grade lymphomas. Methods: Fluorescence in situ hybridization (FISH) was used to detect DUSP22 and 76 cases with indolent lymphoma were evaluated for DUSP22 expression. Thirty-nine had follicular lymphoma (FL), 30 had marginal zone lymphoma (MZL) and 7 had chronic lymphocytic leukemia (CLL). Results: DUSP22 expression was detected in 17 cases (22.3%). The mean overall survival (OS) was found to be longer in cases without DUSP22 compared to cases with DUSP22 expression while event-free survival (EFS) was not different between the cases according to the DUSP22 expression. In univariate analysis, stage (early-stage disease p=0.0001), gender (female p=0.009) and DUSP22 expression (p=0.018) were found to be independent prognostic factors according to Cox regression analysis. . Conclusion: There is no sufficient data about the clinical and/or prognostic significance of DUSP22 rearrangement in lymphomas except ALK (-) anaplastic large cell lymphoma. We found that DUSP22 is poor prognostic indicator in cases with low grade lymphomas.

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Bu Makaleye Atıf Yap

Buyuksimsek, M., Paydas, S., Bagir, E. K., Ergin, M., Seydaoglu, G. (2022). Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas. Eurasian Journal of Medicine and Oncology, Cilt: 5 - Sayı: 4, 327–331. https://ajindex.com/articles/509486

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Kaynakça (14)

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