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Dergiler / Eurasian Journal of Medicine / 2019 / Cilt: 51 - Sayı: 1

Effect of Prostaglandin E1 Analog Misoprostol in An Ovalbumin-Induced Allergic Rhinitis Model

İrfan ÇINAR
Sevilay ÖZMEN
Zafer BAYRAKTUTAN
Vahit MUTLU
Erdem TOKTAY
Arzu BİLEN
Muhammed YAYLA
Zülküf KAYA
Nihal Efe ATİLLA
Harun UN
Sayfa
75–79
Yayın Tarihi
2022-10-18
DOI
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The best improvement in serum IgE levels was seen in the misoprostol alone and combination treatment groups.Conclusion: We suggest that prostaglandins should be considered in the treatment of AR, and that the effects of these types of drugs should be tested clinically in patients.

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Amaç & Hipotez:Objective: The aim of the present study was to demonstrate the effects of misoprostol in ovalbumin-induced allergic rhinitis (AR).
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Temel Bulgular & Veri:The second purpose was to compare the effect profile of the combination of an antihistamine with misoprostol during treatment of AR.Materials and Methods: Twenty-five adult male rats were used and were randomly classified into five groups (n=5): healthy+saline, AR, AR and desloratadine (D)-treated group, AR and misoprostol (M)-treated group, and AR and combined-treated group.Results: Desloratadine administration had significantly lower nasal symptoms than the AR group, but nasal symptoms in the AR+M group were better than those in the AR+D group.
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Sonuç & Katkı:The best improvement in serum IgE levels was seen in the misoprostol alone and combination treatment groups.Conclusion: We suggest that prostaglandins should be considered in the treatment of AR, and that the effects of these types of drugs should be tested clinically in patients.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: The aim of the present study was to demonstrate the effects of misoprostol in ovalbumin-induced allergic rhinitis (AR). The second purpose was to compare the effect profile of the combination of an antihistamine with misoprostol during treatment of AR.Materials and Methods: Twenty-five adult male rats were used and were randomly classified into five groups (n=5): healthy+saline, AR, AR and desloratadine (D)-treated group, AR and misoprostol (M)-treated group, and AR and combined-treated group.Results: Desloratadine administration had significantly lower nasal symptoms than the AR group, but nasal symptoms in the AR+M group were better than those in the AR+D group. The best improvement in serum IgE levels was seen in the misoprostol alone and combination treatment groups.Conclusion: We suggest that prostaglandins should be considered in the treatment of AR, and that the effects of these types of drugs should be tested clinically in patients.

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Bu Makaleye Atıf Yap

ÇINAR, İ., ÖZMEN, S., BAYRAKTUTAN, Z., MUTLU, V., TOKTAY, E., BİLEN, A., YAYLA, M., KAYA, Z., ATİLLA, N. E., UN, H. (2022). Effect of Prostaglandin E1 Analog Misoprostol in An Ovalbumin-Induced Allergic Rhinitis Model. Eurasian Journal of Medicine, Cilt: 51 - Sayı: 1, 75–79. https://ajindex.com/articles/508939

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Kaynakça (14)

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