The disease affectsalmost every organ in the body, including bone, skin, lung, lymph nodes, hypothalamopituitaryaxis, liver, spleen, and other sites.2,4 Thyroid involvement in LCH is rare and usually seen inadults.5 When it occurs in children, it is often accompanied by multisystemic involvement.6,7Because of its rarity, LCH with involvement of the thyroid gland can cause delays in diagnosisand misdiagnosis.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:Langerhans cell histiocytosis (LCH) is a rare neoplastic disease of dendritic cells with indefiniteetiology and pathogenesis.1 The incidence rate of the disease is 4.0–5.4 per 1 million individuals,and the mortality rate is about 3% in adults.2,3 LCH is often encountered in pediatric patientsand can be observed as single-organ involvement or multisystemic disease.
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Temel Bulgular & Veri:Langerhans cell histiocytosis (LCH) is a rare neoplastic disease of dendritic cells with indefiniteetiology and pathogenesis.1 The incidence rate of the disease is 4.0–5.4 per 1 million individuals,and the mortality rate is about 3% in adults.2,3 LCH is often encountered in pediatric patientsand can be observed as single-organ involvement or multisystemic disease.
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Sonuç & Katkı:The disease affectsalmost every organ in the body, including bone, skin, lung, lymph nodes, hypothalamopituitaryaxis, liver, spleen, and other sites.2,4 Thyroid involvement in LCH is rare and usually seen inadults.5 When it occurs in children, it is often accompanied by multisystemic involvement.6,7Because of its rarity, LCH with involvement of the thyroid gland can cause delays in diagnosisand misdiagnosis.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Abstract
Langerhans cell histiocytosis (LCH) is a rare neoplastic disease of dendritic cells with indefiniteetiology and pathogenesis.1 The incidence rate of the disease is 4.0–5.4 per 1 million individuals,and the mortality rate is about 3% in adults.2,3 LCH is often encountered in pediatric patientsand can be observed as single-organ involvement or multisystemic disease. The disease affectsalmost every organ in the body, including bone, skin, lung, lymph nodes, hypothalamopituitaryaxis, liver, spleen, and other sites.2,4 Thyroid involvement in LCH is rare and usually seen inadults.5 When it occurs in children, it is often accompanied by multisystemic involvement.6,7Because of its rarity, LCH with involvement of the thyroid gland can cause delays in diagnosisand misdiagnosis.
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Bu Makaleye Atıf Yap
Hasanov, I., Aliyev, A., Ismayilov, R., Aliyev, A. (2022). Langerhans Cell Histiocytosis of Thyroid Gland in a Child: A Case Report and Literature Review. Eurasian Journal of Medicine, Cilt: 53 - Sayı: 2, 148–151. https://ajindex.com/articles/508810
Haroche J, Cohen-Aubart F, Rollins BJ, et al. Histiocytoses: emerging neoplasia behind inflammation. Lancet Oncol. 2017;18(2):e113–125. [Crossref] 2. Emile JF, Abla O, Fraitag S, et al. Review Article Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 2016;127(22):2672–2681. [Crossref] 3. Patten DK, Wani Z, Tolley N. Solitary langerhans histiocytosis of the thyroid gland: a case report and literature review. Head Neck Pathol. 2012;6(2):279–289. [Crossref] 4. Attakkil A, Thorawade V, Jagade M, Kar R, Paxparelka RK. Isolated langerhans histiocytosis in thyroid: thyroidectomy or chemotherapy? J Clin Diagnostic Res. 2015;9(9):XD01–XD03. [Crossref] 5. Lollar K, Farrag TY, Cao D, Niparko J, Tufano RP. Langerhans cell histiocytosis of the thyroid gland. Am J Otolaryngol. 2008;29(3):201–204. [Crossref] 6. Tajik P, Nazari S, Javaherizadeh H. Langerhans cell histiocytosis with thyroid involvement in a 3 year-old child – a case report. Pol Przegl Chir. 2012;84(8):411–414. [Crossref] 7. Lin CH, Lin WC, Chiang IP, Ho YJ, Peng TC, Wu KH. Langerhans cell histiocytosis with thyroid and lung involvement in a child: a case report. J Pediatr Hematol Oncol. 2010;32(4):309–11. [Crossref] 8. Yokoyama S, Nakaoka T, Fukao D, et al. Pulmonary Langerhans cell histiocytosis with thyroid involvement manifesting as recurrent bilateral pneumothorax and tension bullae in a 3-year-old child. Int J Surg Case Rep. 2019;60:239–243. [Crossref] 9. He Y, Xie J, Zhang H, Wang J, Su X, Liu D. Delayed diagnosis of langerhans cell histiocytosis presenting with thyroid involvement and respiratory failure: a pediatric case report. J Pediatr Hematol Oncol. 2020;42(8):e810-e812. [Crossref] 10. Xia CX, Li R, Wang ZH, et al. A rare cause of goiter: langerhans cell histiocytosis of the thyroid. Endocr J. 2012;59(1):47–54. [Crossref] 11. Ozisik H, Yurekli BS, Demir D, et al. Langerhans cell histiocytosis of the thyroid together with papillary thyroid carcinoma. Hormones (Athens). 2020;19(2):253-259. [Crossref] 12. Sangtian J, Riangwiwat T, Triamchaisri S, Kanoksil W, Sriphrapradang C. Fine-needle aspiration biopsy of langerhans cell histiocytosis of thyroid gland. J Clin Endocrinol Metab. 2015;100(1):15– 16. [Crossref] 13. Long Q, Shaoyan W, Hui W. 18F-fluorodeoxyglucose positron emission tomography/computed tomography for primary thyroid langerhans histiocytosis: a case report and literature review. Indian J Nucl Med. 2015;30(4):328–330. [Crossref]