KaydedilenlerDerginizi ekleyin

Dergiler / Eurasian Journal of Medical Investigation / 2019 / Cilt: 3 - Sayı: 2

The Effect of Taxifolin in the Treatment of Renal Damage Induced by Ischemia Reperfusion in Rats

Mecdi Gurhan BALCİ
Huseyin EKEN
Mine GULABOGLU
Sayfa
150–155
Yayın Tarihi
2022-10-12
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In the group treated with taxifolin, renal damage observed in the renal ischemia group was found to be greatly healed histopathologically.Conclusion: It has been concluded that the use of taxifolin may be useful in correcting renal ischemia reperfusion injury.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objectives: Renal ischemia-reperfusion damage can develop following the conditions such as shock and trauma.
📊
Temel Bulgular & Veri:The purpose of study is to examinethe effect of taxifolin on renal damage induced by ischemia reperfusion in rats biochemically and histopathologically.Methods: A total of 18 albino wistar strain male rats were used in the experiment.
💡
Sonuç & Katkı:In the group treated with taxifolin, renal damage observed in the renal ischemia group was found to be greatly healed histopathologically.Conclusion: It has been concluded that the use of taxifolin may be useful in correcting renal ischemia reperfusion injury.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objectives: Renal ischemia-reperfusion damage can develop following the conditions such as shock and trauma. Cell function disorder and even necrosis can be seen during ischemia. For this reason, it is inevitable to perform the reper-fusion process as soon as possible. Taxifolin is a flavanone that is found in onions, thistle and fir bark. The purpose of study is to examinethe effect of taxifolin on renal damage induced by ischemia reperfusion in rats biochemically and histopathologically.Methods: A total of 18 albino wistar strain male rats were used in the experiment. The animals were divided into three group: Renal ischemia reperfusion group. The group which was given 50 mg/kg taxifolin after renal ischemia reperfu-sion. The group which was applied sham operation.Results: Compared with malondialdehyde levels, total glutathione levels, COX-1 and COX-2 activities of the groups: There was a statistically significant difference between the group receiving renal ischemia reperfusion and the group receiving taxifolin after renal ischemia reperfusion. In the group treated with taxifolin, renal damage observed in the renal ischemia group was found to be greatly healed histopathologically.Conclusion: It has been concluded that the use of taxifolin may be useful in correcting renal ischemia reperfusion injury.

🔖

Bu Makaleye Atıf Yap

BALCİ, M. G., EKEN, H., GULABOGLU, M. (2022). The Effect of Taxifolin in the Treatment of Renal Damage Induced by Ischemia Reperfusion in Rats. Eurasian Journal of Medical Investigation, Cilt: 3 - Sayı: 2, 150–155. https://ajindex.com/articles/508732

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (15)

  1. Sadis C, Teske G, Stokman. Nicotine protects kidney from re-nal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway. PLoS ONE 2007;2:469
  2. Zimmerman BJ, Granger DN. Reperfusion injury. The Surgical clinics of North America 1992;72:65–83
  3. Edelstein CL, Ling H, Schrier RW. The nature of renal cell injury. Kidney international 1997;51:1341–51
  4. Sener G, Sener E, Sehirli O, Oğünç AV, Cetinel S, Gedik N, et al. Ginkgo biloba extract ameliorates ischemia reperfusion-induced renal injury in rats. Pharmacological research: the of-ficial journal of the Italian Pharmacological Society 2005;52: 216–222
  5. Li C, Jackson RM. Reactive species mechanisms of cellular hypoxia-reoxygenation injury.Am J Physiol Cell Physiol 2002; 282:227–41
  6. Lindsay TF, Liauw S, Romaschin AD, Walker PM. The effect of ischemia/reperfusion on adenine nucleotide metabolism and xanthine oxidase production in skeletal muscle. J Vasc Surg 1990;12:8–15
  7. Del Maestro RF Goulart M, Batoreu MC, Rodrigues AS, Laires A, Rueff J. Lipoperoxidation products and thiol antioxidants in chromium exposed workers. Mutagenesis 2005;20:311–5
  8. Gholampour F, Khangah L, Vatanparast J, Karbalaei-Heidari HR, Owji SM, Bahaoddini A. The role of nitric oxide in the pro-tective action of remote ischemic per-conditioning against ischemia/reperfusion-induced acute renal failure in rat. Iran J Basic Med Sci 2018;21:600–6
  9. Suleyman H, Demircan B, Karagoz Y. Anti-inflammatory and side effects of cyclooxygenase inhibitors. Pharmacological Reports 2007;59:247–58
  10. Vilanova JM, Figueras-Aloy J, Rosello J, Gomez G, Gelpi E, Jimenez R. Arachidonic acid metabolites in CSF in hypoxic-ischaemic encephalopathy of newborn infants. Acta Paediat-rica 1998;87:588–92
  11. Carden DL, Granger DN. Phatophsiology of ischemia-reperfu-sion injury. J Pathol 2000;190:255–66
  12. Chamoun F, Burne M, O’Donnel M, Rabb H. Pathophsiologic role of selectins and their ligands in ischemia reperfusion in-jury Front Biosci 2000;5:103–9
  13. Ormrod DJ, Harrison GL, Miller TE. Inhibition of neutrophil my-eloperoxidase activity by selected tissues. J Pharmacol Meth-ods 1987;18:137–42
  14. Wang Q, Wang L, Li G, Ye B. A simple and sensitive method for determination of taxifolin on palladium nanoparticles sup-ported poly (diallyldimethylammonium chloride) functional-ized graphene modified electrode. Talanta 2017;164:323–9
  15. Topal F, Nar M, Gocer H, Kalin P, Kocyigit UM, Gulcin I, et al. Antioxidant activity of t