KaydedilenlerDerginizi ekleyin

Dergiler / Eurasian Journal of Medical Investigation / 2021 / Cilt: 5 - Sayı: 2

Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma

Faysal DANE
Özkan ALAN
Bülent EROL
Zerrin ÖZGEN
Tuğba BAŞOĞLU
Hüseyin Kemal TÜRKÖZ
Selver IŞIK
Nazım Can DEMİRCAN
Özlem ERCELEP
Perran Fulden YUMUK
Rukiye ARIKAN
Tuğba Akın TELLİ
Nisanur SARIYER
Alper YAŞAR
Abdussamet ÇELEBİ
Ömer SOFULLU
Sayfa
256–262
Yayın Tarihi
2022-10-12
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

MedianOS of patients with high PNI (≥48.2) was significantly longer than patients with low PNI (

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objectives: Prognostic nutritional index (PNI) is an inflammation-based score which was found to be predictive ofsurvival for different types of cancer.
📊
Temel Bulgular & Veri:Aim of present study is to investigate the association between PNI and survivaloutcomes in patients with soft tissue sarcoma (STS) operated with curative intent.
💡
Sonuç & Katkı:MedianOS of patients with high PNI (≥48.2) was significantly longer than patients with low PNI (
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objectives: Prognostic nutritional index (PNI) is an inflammation-based score which was found to be predictive ofsurvival for different types of cancer. Aim of present study is to investigate the association between PNI and survivaloutcomes in patients with soft tissue sarcoma (STS) operated with curative intent. Methods: We retrospectively collected data of 86 patients with localized STS. Preoperative PNI was calculated with thefollowing formula:10×serum albumin (g/dL)+0.005×total lymphocyte count (per mm3 ). Patients were classified into 2groups based on median PNI value. Results: Median age was 52.5 (18-86) years. There were 49 male and 37 female patients. Most common histology wasliposarcoma (26.7%). Our cohort mainly included stage 3 (69.8%) and grade 3 (66.3%) tumors. Radiotherapy and chemotherapy were applied to 69.8% and 48.8% of patients, respectively. Median value of PNI was 48.2 (25.5-68.0). Medianfollow-up duration was 25 months (3-120). Median overall survival (OS) was 84.6 months (95% CI, 72.0-97.3). MedianOS of patients with high PNI (≥48.2) was significantly longer than patients with low PNI (

🔖

Bu Makaleye Atıf Yap

DANE, F., ALAN, Ö., EROL, B., ÖZGEN, Z., BAŞOĞLU, T., TÜRKÖZ, H. K., IŞIK, S., DEMİRCAN, N. C., ERCELEP, Ö., YUMUK, P. F., ARIKAN, R., TELLİ, T. A., SARIYER, N., YAŞAR, A., ÇELEBİ, A., SOFULLU, Ö. (2022). Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma. Eurasian Journal of Medical Investigation, Cilt: 5 - Sayı: 2, 256–262. https://ajindex.com/articles/508601

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Burningham Z, Hashibe M, Spector L, Schiffman JD. The epidemiology of sarcoma. Clin Sarcoma Res 2012;2:14
  2. Lindberg RD, Martin RG, Romsdahl MM, Barkley HT Jr. Conservative surgery and postoperative radiotherapy in 300 adults with soft-tissue sarcomas. Cancer 1981;47:2391–7
  3. Weitz J, Antonescu CR, Brennan MF. Localized extremity soft tissue sarcoma: improved knowledge with unchanged survival over time. J Clin Oncol 2003;21:2719–25
  4. NIH. SEER Stat Fact Sheets: Soft Tissue Including Heart. National Cancer Institute, Surveillance Epidemiology and End Results. Available on: http://seer.cancer.gov/statfacts/html/ soft.html (Accessed December 19, 2020)
  5. Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C, Flavell RA. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer 2013;13:759–71
  6. Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A. The combined use of the neutrophil-lymphocyte ratio and C-reactive protein level as prognostic predictors in adult patients with soft tissue sarcoma. J Surg Oncol 2013;108:481–5
  7. Liang Y, Xiao W, Guan YX, Wang W, Chen HY, Fang C, et al. Prognostic value of the C-reactive protein/Albumin Ratio (CAR) in patients with operable soft tissue sarcoma. Oncotarget 2017;8:98135–47
  8. Fang E, Wang X, Feng J, Zhao X. The prognostic role of Glasgow Prognostic Score and C-reactive protein to albumin ratio for sarcoma: a system review and meta-analysis. Dis Markers 2020;2020:8736509
  9. Maretty-Kongstad K, Aggerholm-Pedersen N, Keller J, Safwat A. A validated prognostic biomarker score for adult patients with nonmetastatic soft tissue sarcomas of the trunk and extremities. Transl Oncol 2017;10:942–8
  10. Liang Y, Wang W, Que Y, Guan Y, Xiao W, Fang C, et al. Prognostic value of the fibrinogen/albumin ratio (FAR) in patients with operable soft tissue sarcoma. BMC Cancer 2018;18942
  11. Onodera T, Goseki N, Kosaki G. Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients. Nihon Geka Gakkai Zasshi 1984;85:1001–5. [Article in Japanese] 12. Li D, Yuan X, Liu J, Li C, Li W. Prognostic value of prognostic nutritional index in lung cancer: a meta-analysis. J Thorac Dis 2018;10:5298–307
  12. Saito H, Kono Y, Murakami Y, Kuroda H, Matsunaga T, Fukumoto Y, et al. Influence of prognostic nutritional index and tumor markers on survival in gastric cancer surgery patients. Langenbecks Arch Surg 2017;402:501–7
  13. Peng D, Gong YQ, Hao H, He ZS, Li