Dergiler / Eurasian Journal of Emergency Medicine / 2017 / Cilt: 16 - Sayı: 2

Diagnostic Value of Cyclophilin A in Acute Ischemic Stroke

Sayfa
54–56
Yayın Tarihi
2022-10-11
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These levels were significantly higher in the patient group than in the control group (p

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: The early diagnosis and treatment of patients presenting to the emergency department symptoms of stroke can significantly reduce mortality and morbidity rates associated with it.
📊
Temel Bulgular & Veri:This study aimed to investigate the diagnostic value of serum yclophilin A levels in our study group who presented to the emergency department with symptoms of acute ischemic stroke.Materials and Methods: In total, 114 patients diagnosed with acute ischemic stroke between October 2013 and October 2014 and a control group of 66 healthy volunteers were included.
💡
Sonuç & Katkı:These levels were significantly higher in the patient group than in the control group (p
🔬Tür:Araştırma Makalesi
📍Kapsam:2013 Verileri
⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: The early diagnosis and treatment of patients presenting to the emergency department symptoms of stroke can significantly reduce mortality and morbidity rates associated with it. This study aimed to investigate the diagnostic value of serum yclophilin A levels in our study group who presented to the emergency department with symptoms of acute ischemic stroke.Materials and Methods: In total, 114 patients diagnosed with acute ischemic stroke between October 2013 and October 2014 and a control group of 66 healthy volunteers were included. Cyclophilin A levels in the patient and control groups were compared. Results: The median cyclophilin A levels in the patient and control groups measured at the time of presentation were 13.47 (11.97-17.92) ng/mL and 11.54 (8.48-16.22) ng/mL, respectively. These levels were significantly higher in the patient group than in the control group (p

🔖

Bu Makaleye Atıf Yap

ALTAY, D. U., AKSÜT, N., KARATAŞ, M., BEŞLİOĞLU, N., ÖREM, A., MENTEŞE, A., KARACA, Y., ERYİĞİT, U., TATLI, Ö., ŞAHİN, A. (2022). Diagnostic Value of Cyclophilin A in Acute Ischemic Stroke. Eurasian Journal of Emergency Medicine, Cilt: 16 - Sayı: 2, 54–56. https://ajindex.com/articles/508082

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (14)

  1. Alexander RW. Theodore Cooper Memorial Lecture. Hypertension and the pathogenesis of atherosclerosis. Oxidative stress and the mediation of arterial inflammatory response: a new perspective. Hypertension 1995
  2. [CrossRef] Storey KB, Storey JM. Protein Adaptations and Signal Transduction: Else- vier Science
  3. Galat A. Peptidylproline cis-trans-isomerases: immunophilins. Eur J Bio- chem 1993
  4. [CrossRef] Jin ZG, Lungu AO, Xie L, Wang M, Wong C, Berk BC. Cyclophilin A is a proinflammatory cytokine that activates endothelial cells. Arterioscler Thromb Vasc Biol 2004
  5. [CrossRef] Nigro P, Satoh K, O'Dell MR, Soe NN, Cui Z, Mohan A, et al. Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipopro- tein E-deficient mice. J Exp Med 2011
  6. [CrossRef] Satoh K, Matoba T, Suzuki J, O'Dell MR, Nigro P, Cui Z, et al. Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation. Circulation 2008
  7. [CrossRef] Satoh K, Nigro P, Matoba T, O'Dell MR, Cui Z, Shi X, et al. Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med 2009
  8. [CrossRef] Satoh K, Fukumoto Y, Shimokawa H. Rho-kinase: important new thera- peutic target in cardiovascular diseases. Am J Physiol Heart Circ Physiol 2011
  9. [CrossRef] Shimokawa H, Takeshita A. Rho-kinase is an important therapeutic tar- get in cardiovascular medicine. Arterioscler Thromb Vasc Biol 2005
  10. [CrossRef] Suzuki J, Jin ZG, Meoli DF, Matoba T, Berk BC. Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells. Circ Res 2006
  11. [CrossRef] Jin ZG, Melaragno MG, Liao DF, Yan C, Haendeler J, Suh YA, et al. Cyclo- philin A is a secreted growth factor induced by oxidative stress. Circ Res 2000
  12. [CrossRef] Liao DF, Jin ZG, Baas AS, Daum G, Gygi SP, Aebersold R, et al. Purification and identification of secreted oxidative stress-induced factors from vas- cular smooth muscle cells. J Biol Chem 2000
  13. [CrossRef] Damsker JM, Bukrinsky MI, Constant SL. Preferential chemotaxis of ac- tivated human CD4+ T cells by extracellular cyclophilin A. J Leukoc Biol 2007
  14. [CrossRef] Kim H, Kim WJ, Jeon ST, Koh EM, Cha HS, Ahn KS, et al. Cyclophilin A may contribute to the inflammatory processes in rheumatoid arthritis through induction of matrix degr