KaydedilenlerDerginizi ekleyin

Dergiler / European Journal of Rheumatology / 2020 / Cilt: 7 - Sayı: 1

Successful treatment of pediatric Tolosa-Hunt syndrome with adalimumab

Randy Q. CRON
Jameson WIENER
Sayfa
82–84
Yayın Tarihi
2022-10-18
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: Adalimumab, a subcutaneous TNFi, appears to be an effective treatment for corticosteroid- dependent THS.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objective: Tolosa-Hunt syndrome (THS) is a rare disease characterized by painful unliteral ophthalmoplegia and headache.
📊
Temel Bulgular & Veri:We have reviewed the THS literature, including 2 adult THS patients who have been successfully treated with intravenous TNFi, infliximab.
💡
Sonuç & Katkı:Conclusion: Adalimumab, a subcutaneous TNFi, appears to be an effective treatment for corticosteroid- dependent THS.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: Tolosa-Hunt syndrome (THS) is a rare disease characterized by painful unliteral ophthalmoplegia and headache. THS is caused by granulomatous inflammation of the cavernous sinus, and its diagnosis is typically made by elimination and exclusion. The characteristic pain can typically be managed with steroid therapy, but relapses are common. Additional therapy is needed for refractory or recurrent cases. Methods: Herein, using the electronic medical record with institutional review board approval, we report a case of a pediatric patient diagnosed with corticosteroid-dependent THS. The child was effectively treated with the tumor necrosis factor inhibitor (TNFi), adalimumab. We have reviewed the THS literature, including 2 adult THS patients who have been successfully treated with intravenous TNFi, infliximab. Results: This is the first report in the scientific literature to effectively treat pediatric THS, and also the first such case to use adalimumab to successfully treat THS. Conclusion: Adalimumab, a subcutaneous TNFi, appears to be an effective treatment for corticosteroid- dependent THS.

🔖

Bu Makaleye Atıf Yap

CRON, R. Q., WIENER, J. (2022). Successful treatment of pediatric Tolosa-Hunt syndrome with adalimumab. European Journal of Rheumatology, Cilt: 7 - Sayı: 1, 82–84. https://ajindex.com/articles/503776

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (17)

  1. Hunt WE. Tolosa-Hunt syndrome: one cause of painful ophthalmoplegia. J Neurosurg 1976
  2. [CrossRef ] 2. Amrutkar C, Burton EV. Tolosa-Hunt Syndrome. In: StatPearls. Treasure Island (FL)
  3. Tsirigotaki M, Ntoulios G, Lioumpas M, Voutoufianakis S, Vorgia P. Tolosa-Hunt Syndrome: Clinical Manifestations in Children. Pediatr Neurol 2019
  4. [CrossRef ] 4. Kline LB, Hoyt WF. The Tolosa-Hunt syndrome. J Neurol Neurosurg Psychiatry 2001
  5. [CrossRef] 5. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 2018
  6. [CrossRef ] 6. Smith JL, Taxdal DS. Painful ophthalmoplegia. The Tolosa-Hunt syndrome. Am J Ophthalmol 1966
  7. [CrossRef ] 7. Sondheimer FK, Knapp J. Angiographic findings in the Tolosa-Hunt syndrome: painful ophthalmoplegia. Radiology 1973
  8. [CrossRef ] 8. Adams A, Warner A. Painful ophthalmoplegia: report of a case with cerebral involvement and psychiatric complications. Bull Los Angeles Neurol Soc 1975
  9. Inzitari D, Sita D, Marconi G, Barontini F. The Tolosa- Hunt syndrome: further clinical and pathogenetic considerations based on the study of eight cases. J Neurol 1981
  10. [CrossRef ] 10. Cerisola A, Gonzalez G, Scavone C. Tolosa-Hunt syndrome preceded by facial palsy in a child. Pediatr Neurol 2011
  11. [CrossRef ] 11. Yousem DM, Atlas S, Grossman R, Sergott R, Savino P, Bosley T. MR imaging of Tolosa-Hunt syndrome. Am J Neuroradiol 1989
  12. Goto Y, Hosokawa S, Goto I, Hirakata R, Hasuo K. Abnormality in the cavernous sinus in three patients with Tolosa-Hunt syndrome: MRI and CT findings. J Neurol Neurosurg Psychiatry 1990
  13. [CrossRef ] 13. Perez CA, Evangelista M. Evaluation and Management of Tolosa-Hunt Syndrome in Children: A Clinical Update. Pediatr Neurol 2016
  14. [CrossRef ] 14. Gerriets V, Khaddour K. Tumor Necrosis Factor (TNF) Inhibitors. In: StatPearls. Treasure Island (FL)
  15. Lapadula G, Marchesoni A, Armuzzi A, Blandizzi C, Caporali R, Chimenti S, et al. Adalimumab in the treatment of immune-mediated diseases. Int J Immunopathol Pharmacol 2014
  16. [CrossRef] 16. Halabi T, Sawaya R. Successful Treatment of Tolosa- Hunt Syndrome after a Single Infusion of Infliximab. J Clin Neurol 2018
  17. [CrossRef] 17. O’Conner G, Hutchinson M. Tolosa-Hunt syndrome responsive to infliximab therapy. J