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Dergiler / Erciyes Medical Journal / 2021 / Cilt: 43 - Sayı: 2

Chromosomal Evaluation Results for TransgenderIndividuals and Questioning the Necessity of Karyotyping

Tufan ÇANKAYA
Ayfer ÜLGENALP
Duygu Onur CURA
Hande ÖZKALAYCI
Sayfa
166–169
Yayın Tarihi
2022-10-11
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

From the find ings of this study and the literature, we suggest that chromosomal analysis is unnecessary unless evidence for another disorderof sex development is found alongside clinical, laboratory, and radiological findings.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Gender dysphoria is a condition where an individual is discontent with their assigned gender.
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Temel Bulgular & Veri:Materials and Methods: Karyotype analyses were used to evaluate 67 unrelated individuals.
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Sonuç & Katkı:From the find ings of this study and the literature, we suggest that chromosomal analysis is unnecessary unless evidence for another disorderof sex development is found alongside clinical, laboratory, and radiological findings.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: Gender dysphoria is a condition where an individual is discontent with their assigned gender. Karyotyping is apart of the transition period before hormone therapy to detect the biological gender for most professionals in many countries.Thus, we discussed the requirements for chromosomal analysis of individuals with gender dysphoria considering clinical andgenetic findings. Materials and Methods: Karyotype analyses were used to evaluate 67 unrelated individuals. Results: Five individuals transitioned from male to female, and the rest transitioned from female to male. No chromosomal ab normalities and/or chromosomal rearrangements were observed, except for an individual who had mosaic Turner syndrome. Conclusion: This study evaluates the results of chromosomal analysis of individuals with gender dysphoria. From the find ings of this study and the literature, we suggest that chromosomal analysis is unnecessary unless evidence for another disorderof sex development is found alongside clinical, laboratory, and radiological findings.

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Bu Makaleye Atıf Yap

ÇANKAYA, T., ÜLGENALP, A., CURA, D. O., ÖZKALAYCI, H. (2022). Chromosomal Evaluation Results for TransgenderIndividuals and Questioning the Necessity of Karyotyping. Erciyes Medical Journal, Cilt: 43 - Sayı: 2, 166–169. https://ajindex.com/articles/502293

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Kaynakça (14)

  1. Arcelus J, Bouman WP, Van Den Noortgate W, Claes L, Witcomb G, et al. Systematic review and meta-analysis of prevalence studies in transsexualism. Eur Psychiatry 2015; 30(6): 807–15
  2. Hengstschläger M, van Trotsenburg M, Repa C, Marton E, Huber JC, Bernaschek G. Sex chromosome aberrations and transsexualism. Fertil Steril 2003; 79(3): 639–40
  3. Bearman G. Karyotyping and genetics in the transgendered population. In: Ettner R, Monstrey S, Eyler AE, editors. Principles of transgender medicine and surgery. Binghamton: The Haworth Press; 2007.p.223–32
  4. Wylie KR, Steward D. A consecutive series of 52 transsexual people presenting for assessment and chromosomal analysis at a gender identity clinic. Int J Transgend 2008; 10(3-4): 147–8
  5. Vujovic S, Popovic S, Sbutega-Milosevic G, Djordjevic M, Gooren L. Transsexualism in Serbia: a twenty-year follow-up study. J Sex Med 2009; 6(4): 1018–23
  6. Inoubli A, De Cuypere G, Rubens R, Heylens G, Elaut E, Van Caenegem E, et al. Karyotyping, is it worthwhile in transsexualism? J Sex Med 2011; 8(2): 475–8
  7. Auer MK, Fuss J, Stalla GK, Athanasoulia AP. Twenty years of endocrinologic treatment in transsexualism: analyzing the role of chromosomal analysis and hormonal profiling in the diagnostic work-up. Fertil Steril 2013; 100(4): 1103–10
  8. Davies GW, Parkinson J. Gender dysphoria in Klinefelter’s syndrome: three cases. Australas Psychiatry 2018; 26(3): 313–4
  9. Fernández R, Guillamón A, Gómez-Gil E, Esteva I, Almaraz MC, CortésCortés J, et al. Analyses of karyotype by G-banding and high-resolution microarrays in a gender dysphoria population. Genes Genomics 2018; 40(5): 465–73
  10. Bağcaz A, Boduroğlu OK, Başar K. Chromosome Analysis in the Assessment for Gender Affirmation Process: A Retrospective Study. Türk Psikiyatri Dergisi 2019; 30(3): 157–62
  11. Khandelwal A, Agarwal A, Jiloha RC. A 47, XXY female with gender identity disorder. Arch Sex Behav 2010; 39(5): 1021–3
  12. Herlihy AS, Halliday JL, Cock ML, McLachlan RI. The prevalence and diagnosis rates of Klinefelter syndrome: an Australian comparison. Med J Aust 2011; 194(1): 24–8
  13. Klinefelter HF, Reifenstein EC, Albright F. Syndrome characterized by gynaecomastia, aspermatogenesis without a Leydigismi and increased excretion of follicule stimulating hormone. J Clin Endocrinology & Metabolism 1942; 2(11): 615–7
  14. Gardner RJM, Sutherland GR, Shaffer LG. Parental Sex Chromosome Aneuploidy. Chromosome Abnormalities and Genetic Counseling. 4th