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AI InsightConclusion: Patients with serum HbA1c levels of more than 8.9 and a diabetes duration of more than 12 months shouldbe assessed for fungal infections, and genital smear samples should be obtained periodically during follow-up.
📌 3 Maddede Bu Makale
Abstract
Objective: A positive relationship exists between high blood glucose levels and infection prevalence in patients with dia betes. Hyperglycemia may predispose to fungal infections. This study was conducted to compare the frequency of fungalinfections and antifungal agent resistance of culture strains in children with type 1 diabetes mellitus (T1DM) with those inhealthy controls and to assess the relationship between fungal infection and hemoglobin A1c (HbA1c) levels. Materials and Methods: The study population included 67 girls with T1DM and 63 girls without T1DM, immunodefi ciency, or chronic drug use. Blood and urine samples were collected, and genital smear sampling was performed. Sampleswere evaluated in a mycology laboratory, and fluconazole sensitivity of culture samples was determined. Results: Genital complaints were more common among patients with diabetes. Fungal agents were isolated in 55.22% ofpatients with diabetes, where Candida glabrata was the most common strain isolated (46.0%). Meanwhile, Candida albicanswas more common in the control group (40.0%). All strains were fluconazole-sensitive, as strains with native resistance wereexcepted. For serum HbA1c levels, a cutoff value of 8.9 was identified and was related to fungal growth with a reliability of80%. Patients with diabetes for more than 12 months had a higher risk of fungal infection. Conclusion: Patients with serum HbA1c levels of more than 8.9 and a diabetes duration of more than 12 months shouldbe assessed for fungal infections, and genital smear samples should be obtained periodically during follow-up.